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Literature summary extracted from

  • Lee, S.Y.; Kim, H.J.; Lee, W.J.; Joo, S.H.; Jeon, S.J.; Kim, J.W.; Kim, H.S.; Han, S.H.; Lee, J.; Park, S.H.; Cheong, J.H.; Kim, W.K.; Ko, K.H.; Shin, C.Y.
    Differential regulation of matrix metalloproteinase-9 and tissue plasminogen activator activity by the cyclic-AMP system in lipopolysaccharide-stimulated rat primary astrocytes (2008), Neurochem. Res., 33, 2324-2334.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.68 dibutyryl-cAMP slightly increases level of tPA mRNA expression. Concentration-dependently increases tPA activity in both basal and lipopolysaccharide-stimulated rat primary astrocytes. Treatment with 100 micromol increases tPA activity by 757.9% compared with lipopolysaccharide treatment. Differentially modulates MMP-9 and tPA activity through a mechanism related to PKA activation. Co-treatment with lipopolysaccharide and dibutyryl-cAMP does not have an additive effect on tPA mRNA induction Rattus norvegicus
3.4.21.68 IBMX increases tPA activity in lipopolysaccharide-stimulated rat primary astrocytes Rattus norvegicus
3.4.21.68 lipopolysaccharide slightly increases level of tPA mRNA expression. Co-treatment with lipopolysaccharide and dibutyryl-cAMP does not have an additive effect on tPA mRNA induction Rattus norvegicus
3.4.21.68 rolipram increases tPA activity in lipopolysaccharide-stimulated rat primary astrocytes Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.68 astrocytes co-transfected with metalloproteinase-9 or tPA luciferase reporter plasmid and pCMV-beta-galactosidase reporter plasmid Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.68 H89 inhibits dibutyryl-cAMP-mediated changes in tPA activity without affecting metalloproteinase-9 activity Rattus norvegicus
3.4.21.68 lipopolysaccharide decreases tPA activity. Co-treatment with dibutyryl-cAMP and lipopolysaccharide dose-dependently prevents lipopolysaccharide-induced downregulation of tPA activity Rattus norvegicus
3.4.21.68 plasminogen activator inhibitor-1 plays a major role in the regulation of tPA activity Rattus norvegicus
3.4.21.68 Rp-cAMP inhibits dibutyryl-cAMP-mediated changes in tPA activity without affecting metalloproteinase-9 activity Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.68 68000
-
casein zymography or gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.68 Rattus norvegicus
-
Sprague-Dawley rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.68 additional information primary astrocyte Rattus norvegicus
-
3.4.21.68 pup 1- to 2-day-old pups Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.68 Tissue plasminogen activator
-
Rattus norvegicus
3.4.21.68 tPA
-
Rattus norvegicus