Literature summary extracted from

Stanyer, L.; Jorgensen, W.; Hori, O.; Clark, J.B.; Heales, S.J.
Inactivation of brain mitochondrial Lon protease by peroxynitrite precedes electron transport chain dysfunction (2008), Neurochem. Int., 53, 95-101.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.21.53	peroxynitrite	in isolated nonsynaptic brain mitochondria Lon protease is highly susceptible to oxidative inactivation by peroxynitrite. This susceptibility is more pronounced with regard to ATP-stimulated activity, which is inhibited by 75% in the presence of a bolus addition of 1 mM ONOO, whereas basal unstimulated activity is inhibited by 45%. A decline in Lon protease activity precedes electron transport chain dysfunction and ATP-stimulated activity is approximately fivefold more sensitive than basal Lon protease activity. Supplementation of mitochondrial matrix extracts with reduced glutathione, following peroxynitrite exposure, results in partial restoration of basal and ATP-stimulated activity	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.21.53	mitochondrion	in isolated nonsynaptic brain mitochondria Lon protease is highly susceptible to oxidative inactivation by peroxynitrite. This susceptibility is more pronounced with regard to ATP-stimulated activity, which is inhibited by 75% in the presence of a bolus addition of 1 mM ONOO, whereas basal unstimulated activity is inhibited by 45%. A decline in Lon protease activity precedes electron transport chain dysfunction and ATP-stimulated activity is approximately fivefold more sensitive than basal Lon protease activity. Supplementation of mitochondrial matrix extracts with reduced glutathione, following peroxynitrite exposure, results in partial restoration of basal and ATP-stimulated activity	Rattus norvegicus	5739	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.53	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.53	brain	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)