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Literature summary extracted from

  • Kanda, H.; Newton, R.; Klein, R.; Morita, Y.; Gunn, M.D.; Rosen, S.D.
    Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs (2008), Nat. Immunol., 9, 415-423.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 isolation of cDNA encoding ATX from HEC cDNA library and transfection of COS-7 African green monkey kidney cells, recombinant expression and purification and immunoblot analysis for showing that HECs synthesize and secrete ATX Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.39 extracellular
-
 Mus musculus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.39 110000
-
 from HEC cells (isolation from mouse lymph nodes using immunomagnetic beads coupled to antibody MECA-79), SDS-PAGE, immunoblot Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O Mus musculus
-
 lysophosphatidic acid + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.39 glycoprotein
-
 Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 high endothelial venule
-
 Mus musculus
-
3.1.4.39 lymph node
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 lysophosphatidylcholine + H2O
-
 Mus musculus lysophosphatidic acid + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 autotaxin (ATX)
-
 Mus musculus