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Literature summary extracted from

  • Goswami, S.; Angkasekwinai, P.; Shan, M.; Greenlee, K.J.; Barranco, W.T.; Polikepahad, S.; Seryshev, A.; Song, L.Z.; Redding, D.; Singh, B.; Sur, S.; Woodruff, P.; Dong, C.; Corry, D.B.; Kheradmand, F.
    Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma (2009), Nat. Immunol., 10, 496-503.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.36 additional information upregulated in response to allergic stimulation in the airway epithelium Mus musculus

Application

EC Number Application Comment Organism
1.2.1.36 medicine RALDH1 is a negative regulator of allergic inflammation Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.23 additional information allergen-challenged Mmp7-/- mice show less airway hyperreactivity and production of allergic inflammatory cytokines and higher expression of retinal dehydrogenase 1. Inhibition of retinal dehydrogenase 1 restores the asthma phenotype of Mmp7-/- mice and inhibits the responses of lung regulatory T cells, whereas exogenous administration of retinoic acid attenuates the asthma phenotype, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.36 citral
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Mus musculus P24549
-
-
3.4.24.23 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.36 alveolar macrophage
-
 Mus musculus
-
1.2.1.36 epithelial cell airway epithelial cell Mus musculus
-
3.4.24.23 epithelium
-
 Homo sapiens
-
3.4.24.23 respiratory epithelium cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.36 all-trans retinaldehyde + NAD+ + H2O
-
 Mus musculus all-trans retinoic acid + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.36 RalDH1
-
 Mus musculus
1.2.1.36 retinal dehydrogenase 1
-
 Mus musculus
3.4.24.23 Matrix metalloproteinase 7
-
 Homo sapiens
3.4.24.23 MMP7
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.23 physiological function epithelial MMP7 is expressed during asthma and is required for the maximum activity of interleukin 25 in promoting the differentiation of T helper type 2 cells. MMP7 coordinates allergic lung inflammation by activating interleukin 25 while simultaneously inhibiting retinoid-dependent development of regulatory T cells Homo sapiens