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Literature summary extracted from

  • Hartong, D.T.; Dange, M.; McGee, T.L.; Berson, E.L.; Dryja, T.P.; Colman, R.F.
    Novel insights into the contributions of isocitrate dehydrogenases to the Krebs cycle from patients with retinitis pigmentosa (2008), Nat. Genet., 40, 1230-1234.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.41 L98P the mutation is associated with retinitis pigmentosa Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Homo sapiens O43837
-
-
1.1.1.42 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.41 lymphoblast
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 DL-isocitrate + NAD+
-
Homo sapiens 2-oxoglutarate + CO2 + NADH
-
?
1.1.1.42 DL-isocitrate + NADP+
-
Homo sapiens 2-oxoglutarate + CO2 + NADPH
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.41 NAD-IDH
-
Homo sapiens
1.1.1.41 NAD-specific isocitrate dehydrogenase
-
Homo sapiens
1.1.1.42 IDH2
-
Homo sapiens
1.1.1.42 NADP-IDH
-
Homo sapiens
1.1.1.42 NADP-specific isocitrate dehydrogenase
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+
-
Homo sapiens
1.1.1.42 NADP+
-
Homo sapiens