BRENDA - Enzyme Database

Novel insights into the contributions of isocitrate dehydrogenases to the Krebs cycle from patients with retinitis pigmentosa

Hartong, D.T.; Dange, M.; McGee, T.L.; Berson, E.L.; Dryja, T.P.; Colman, R.F.; Nat. Genet. 40, 1230-1234 (2008)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.41
L98P
the mutation is associated with retinitis pigmentosa
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.41
Homo sapiens
O43837
-
-
1.1.1.42
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
lymphoblast
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
DL-isocitrate + NAD+
-
700359
Homo sapiens
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.42
DL-isocitrate + NADP+
-
700359
Homo sapiens
2-oxoglutarate + CO2 + NADPH
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
-
Homo sapiens
1.1.1.42
NADP+
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.41
NAD+
-
Homo sapiens
1.1.1.42
NADP+
-
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.41
L98P
the mutation is associated with retinitis pigmentosa
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.41
lymphoblast
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.41
DL-isocitrate + NAD+
-
700359
Homo sapiens
2-oxoglutarate + CO2 + NADH
-
-
-
?
1.1.1.42
DL-isocitrate + NADP+
-
700359
Homo sapiens
2-oxoglutarate + CO2 + NADPH
-
-
-
?