EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
7.4.2.1 | I394 | site-directed mutagenesis, the mutation strongly affects both transport and signaling with citrulline and other amino acids | Saccharomyces cerevisiae |
7.4.2.1 | additional information | mutation of each of the amino acid residues V381, I382, L383, I384, A385, L387, S388, V389, G390, N391, A393, A396, S398, R399, T400, M401, A403, l404, and A405 to cysteine does not affect transport or signaling by the enzyme | Saccharomyces cerevisiae |
7.4.2.1 | S392C | site-directed mutagenesis, the mutation strongly affects both transport and signaling with citrulline and other amino acids | Saccharomyces cerevisiae |
7.4.2.1 | V386C | site-directed mutagenesis, the mutation strongly affects both transport and signaling with citrulline and other amino acids | Saccharomyces cerevisiae |
7.4.2.1 | V402C | site-directed mutagenesis, the mutation strongly affects both transport and signaling with citrulline and other amino acids | Saccharomyces cerevisiae |
7.4.2.1 | Y395C | site-directed mutagenesis, the mutation strongly affects both transport and signaling with citrulline and other amino acids | Saccharomyces cerevisiae |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.4.2.1 | Arg-Phe-Phe | noncompetitive | Saccharomyces cerevisiae | |
7.4.2.1 | L-Asp-gamma-L-Phe | competitive | Saccharomyces cerevisiae | |
7.4.2.1 | L-Leu-Gly | competitive | Saccharomyces cerevisiae | |
7.4.2.1 | Leu-Met-NH2 | - |
Saccharomyces cerevisiae | |
7.4.2.1 | additional information | inhibition of agonist activity by the inhibitor molecules, overveiw | Saccharomyces cerevisiae |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.4.2.1 | plasma membrane | - |
Saccharomyces cerevisiae | 5886 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.4.2.1 | ATP + H2O + polar amino acid/out | Saccharomyces cerevisiae | - |
ADP + phosphate + polar amino acid/in | - |
? | |
7.4.2.1 | additional information | Saccharomyces cerevisiae | Gap1 is a transporting amino acid transceptor that triggers the activation of the protein kinase A pathway | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.4.2.1 | Saccharomyces cerevisiae | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.4.2.1 | ATP + H2O + citrulline/out | - |
Saccharomyces cerevisiae | ADP + phosphate + citrulline/in | - |
? | |
7.4.2.1 | ATP + H2O + polar amino acid/out | - |
Saccharomyces cerevisiae | ADP + phosphate + polar amino acid/in | - |
? | |
7.4.2.1 | ATP + H2O + polar amino acid/out | Ser388 and Val389 are exposed into the amino acid binding site for transport, also used by agonist action for signaling | Saccharomyces cerevisiae | ADP + phosphate + polar amino acid/in | - |
? | |
7.4.2.1 | additional information | Gap1 is a transporting amino acid transceptor that triggers the activation of the protein kinase A pathway | Saccharomyces cerevisiae | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.4.2.1 | amino acid transceptor | - |
Saccharomyces cerevisiae |
7.4.2.1 | GAP1 | - |
Saccharomyces cerevisiae |
7.4.2.1 | transporting amino acid transceptor | - |
Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
7.4.2.1 | ATP | - |
Saccharomyces cerevisiae |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
7.4.2.1 | 0.105 | - |
L-Asp-gamma-L-Phe | - |
Saccharomyces cerevisiae | |
7.4.2.1 | 0.19 | - |
L-Leu-Gly | - |
Saccharomyces cerevisiae |