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Literature summary extracted from

  • Barta, C.A.; Sachs-Barrable, K.; Feng, F.; Wasan, K.M.
    Effects of monoglycerides on P-glycoprotein: modulation of the activity and expression in Caco-2 cell monolayers (2008), Mol. Pharm., 5, 863-875.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.1 1-monoolein 0.5 mM significantly reduce the P-glycoprotein protein expression, 0.1 mM of 1-monoolein does not have any significant effect on the expression of P-glycoprotein Homo sapiens
7.6.2.1 1-monostearin 0.5 mM significantly reduce the P-glycoprotein protein expression, 0.1 mM of 1-monostearin does not have any significant effect on the expression of P-glycoprotein Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.6.2.1 170000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.1 Caco-2 cell
-
 Homo sapiens
-
7.6.2.1 colonic adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.1 ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?
7.6.2.1 ATP + H2O + rhodamine 123/out
-
 Homo sapiens ADP + phosphate + rhodamine 123/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.1 P-glycoprotein
-
 Homo sapiens
7.6.2.1 P-gp
-
 Homo sapiens