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Literature summary extracted from

  • Bulloj, A.; Leal, M.C.; Surace, E.I.; Zhang, X.; Xu, H.; Ledesma, M.D.; Castano, E.M.; Morelli, L.
    Detergent resistant membrane-associated IDE in brain tissue and cultured cells: relevance to Abeta and insulin degradation (2008), Mol. Neurodegener., 3, 22.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.56 cholesterol membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.56 cytosol cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form Mus musculus 5829
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3.4.24.56 cytosol cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form Rattus norvegicus 5829
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3.4.24.56 membrane cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form. The detergent-resistant membrane-associated enzyme co-localizes with amyloid beta. Distribution and activity is sensitive to manipulation of lipid composition in vitro and in vivo Rattus norvegicus 16020
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3.4.24.56 membrane cytosolic enzyme shows a longer half-life compared with the detergent-resistant membrane-associated form. The detergent-resistant membrane-associated enzyme co-localizes with amyloid beta. Distribution and activity is sensitive to manipulation of lipid composition in vitro and in vivo. Membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE Mus musculus 16020
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Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Mus musculus
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3.4.24.56 Rattus norvegicus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 brain membranes isolated from mouse brain with endogenous reduced levels of cholesterol due to targeted deletion of one seladin-I allele show a reduced amount of IDE Mus musculus
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3.4.24.56 N2aEGFP cell N2a cells stably expressing the vector pEGFP Mus musculus
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3.4.24.56 N2aSW cell N2a cells stably expressing human amyloid prepcursor protein Swedish mutation Mus musculus
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3.4.24.56 Neuro-2a cell neuroblastoma cell Mus musculus
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3.4.24.56 neuron hippocampal neuron Rattus norvegicus
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