Any feedback?
Literature summary extracted from
- Dual mechanism of activation of plant plasma membrane Ca2+-ATPase by acidic phospholipids: evidence for a phospholipid binding site which overlaps the calmodulin-binding site (2008), Mol. Membr. Biol., 25, 539-546.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | Calmodulin | strongly activated by calmodulin | Arabidopsis thaliana |  |
| 7.2.2.10 | additional information | PMCA isoform ACA8 activity is hardly affected by phosphatidylcholine or phosphatidylethanolamine | Arabidopsis thaliana | |
| 7.2.2.10 | phosphatidylinositol 4-monophosphate | 433% stimulation of activity at 1 mM | Arabidopsis thaliana | |
| 7.2.2.10 | phosphatidylserine | 465% stimulation of activity at 1 mM | Arabidopsis thaliana | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.2.2.10 | expressed in Saccharomyces cerevisiae strain K616 | Arabidopsis thaliana |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | A56S | the mutation leads to lowered apparent affinity of the PMCA isoform ACA8 for phosphatidylinositol 4-monophosphate by 2-3fold | Arabidopsis thaliana |
| 7.2.2.10 | additional information | the N-deleted mutant DELTA74-ACA8 is also activated by acidic phospholipids | Arabidopsis thaliana |
| 7.2.2.10 | R59A | the mutation leads to lowered apparent affinity of the PMCA isoform ACA8 for phosphatidylinositol 4-monophosphate by 2-3fold | Arabidopsis thaliana |
| 7.2.2.10 | Y62A | the mutation leads to lowered apparent affinity of the PMCA isoform ACA8 for phosphatidylinositol 4-monophosphate by 2-3fold | Arabidopsis thaliana |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | Ca2+ | dependent on | Arabidopsis thaliana | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | Arabidopsis thaliana | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | ACA8 | - |
Arabidopsis thaliana |
| 7.2.2.10 | plasma membrane Ca2+-ATPase isoform ACA8 | - |
Arabidopsis thaliana |
| 7.2.2.10 | PM Ca2+-ATPase | - |
Arabidopsis thaliana |
| 7.2.2.10 | PMCA | - |
Arabidopsis thaliana |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
