EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.36 | additional information | caspase-1 activation is stimulated by ATP and 120fold lipopolysaccharides | Homo sapiens | |
3.4.22.36 | simvastatin | blocks inhibition of caspase-1 activation, simvastatin acts synergistically with lipopolysaccharides and causes an impairment of non-sterol isoprenoid biosynthesis, the isoprenyl intermediate GGPP could block activation of caspase-1 and interleukin-1beta release, overview | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.22.36 | geranylgeranyl diphosphate | the isoprenyl intermediate of non-sterol isoprenoid biosynthesis blocks activation of caspase-1 | Homo sapiens | |
3.4.22.36 | pralnacasan | a specific caspase-1 inhibitor | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.36 | additional information | Homo sapiens | mevalonate kinase deficiency patients have overactive caspase-1, causing enhanced interleukin-1beta processing and subsequent inflammation in response to bacterial components | ? | - |
? | |
3.4.22.36 | pro-interleukin-18 + H2O | Homo sapiens | - |
interleukin-18 + ? | - |
? | |
3.4.22.36 | pro-interleukin-1beta + H2O | Homo sapiens | caspase-1 activation leads to release of active interleukin-1beta from THP-1 cells, regulation, overview | interleukin-1beta + ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.22.36 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.22.36 | mononuclear cell | high activity in from peripheral blood of mevalonate kinase deficiency patients | Homo sapiens | - |
3.4.22.36 | THP-1 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.22.36 | additional information | mevalonate kinase deficiency patients have overactive caspase-1, causing enhanced interleukin-1beta processing and subsequent inflammation in response to bacterial components | Homo sapiens | ? | - |
? | |
3.4.22.36 | pro-interleukin-18 + H2O | - |
Homo sapiens | interleukin-18 + ? | - |
? | |
3.4.22.36 | pro-interleukin-1beta + H2O | - |
Homo sapiens | interleukin-1beta + ? | - |
? | |
3.4.22.36 | pro-interleukin-1beta + H2O | caspase-1 activation leads to release of active interleukin-1beta from THP-1 cells, regulation, overview | Homo sapiens | interleukin-1beta + ? | - |
? |