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Literature summary extracted from

  • Klaiman, G.; Petzke, T.L.; Hammond, J.; Leblanc, A.C.
    Targets of caspase-6 activity in human neurons and Alzheimer disease (2008), Mol. Cell. Proteomics, 7, 1541-1555.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.59 alpha-actinin-4 + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 alpha-drebrin + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 alpha-spinophilin + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 alpha-tubulin + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 annexin V + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 beta-actin + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 capping protein alpha + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 cofilin I + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 eukaryotic elongation factor 1 + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 ezrin + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 glial fibrillary acidic protein + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 glyceraldehyde-3-phosphate dehydrogenase + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 heat shock protein gp96 precursor + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 Hsp90alpha + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 inhibitor-2 of protein phosphatase 2A + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 inorganic pyrophosphatase + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 additional information Homo sapiens caspase-6 activation occurs early in Alzheimer's disease and sometimes precedes the clinical manifestation of the disease in aged individuals. Early and neuritic activation of caspase-6 in Alzheimer disease can disrupt the cytoskeleton network of neurons, resulting in impaired neuronal structure and function in the absence of cell death. Proteomics analysis of caspase-6-mediated cleavage of human neuronal proteins, cleavage site determinations and cleavage specificity, overview ?
-
 ?
3.4.22.59 neurolysin + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 prolyl endopeptidase + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 protein 14-3-3epsilon + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 protein 14-3-3zeta + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 Rab GDP dissociation factor inhibitor alpha + H2O Homo sapiens
-
 ?
-
 ?
3.4.22.59 valosin-containing protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.59 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.59 neuron primary neurons, active caspase-6 is localized in neuritic plaques, in neuropil threads, and in neurofibrillary tangles containing neurons that are not morphologically apoptotic in nature Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.59 Ac-Val-Glu-Ile-Asp-7-amido-4-trifluoromethylcoumarin + H2O
-
 Homo sapiens Ac-Val-Glu-Ile-Asp + 7-amino-4-trifluoromethylcoumarin
-
 ?
3.4.22.59 alpha-actinin-4 + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 alpha-drebrin + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 alpha-spinophilin + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 alpha-tubulin + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 annexin V + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 beta-actin + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 capping protein alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 cofilin I + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 eukaryotic elongation factor 1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 ezrin + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 glial fibrillary acidic protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 glyceraldehyde-3-phosphate dehydrogenase + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 heat shock protein gp96 precursor + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 Hsp90alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 inhibitor-2 of protein phosphatase 2A + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 inorganic pyrophosphatase + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 additional information caspase-6 activation occurs early in Alzheimer's disease and sometimes precedes the clinical manifestation of the disease in aged individuals. Early and neuritic activation of caspase-6 in Alzheimer disease can disrupt the cytoskeleton network of neurons, resulting in impaired neuronal structure and function in the absence of cell death. Proteomics analysis of caspase-6-mediated cleavage of human neuronal proteins, cleavage site determinations and cleavage specificity, overview Homo sapiens ?
-
 ?
3.4.22.59 neurolysin + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 prolyl endopeptidase + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 protein 14-3-3epsilon + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 protein 14-3-3zeta + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 Rab GDP dissociation factor inhibitor alpha + H2O
-
 Homo sapiens ?
-
 ?
3.4.22.59 valosin-containing protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.59 Csp6
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.59 37
-
 assay at Homo sapiens