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Literature summary extracted from

  • Brozic, P.; Kocbek, P.; Sova, M.; Kristl, J.; Martens, S.; Adamski, J.; Gobec, S.; Lanisnik Rizner, T.
    Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (2009), Mol. Cell. Endocrinol., 301, 229-234.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.62 expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.62 (2Z,2'E)-N,N'-1H-1,5-benzodiazepine-2,4-diylbis(3-phenylprop-2-enamide) 30% inhibition at 0.006 mM Homo sapiens
1.1.1.62 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate 44% inhibition at 0.006 mM Homo sapiens
1.1.1.62 2-nitrophenyl (2E)-3-phenylprop-2-enoate 45% inhibition at 0.006 mM Homo sapiens
1.1.1.62 3,4,5-trimethoxycinnamic acid
-
 Homo sapiens
1.1.1.62 3-(trifluoromethyl)-cinnamic acid
-
 Homo sapiens
1.1.1.62 3-phenoxybenzyl (2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoate 14% inhibition at 0.006 mM Homo sapiens
1.1.1.62 3-phenoxybenzyl (2E)-3-phenylprop-2-enoate 13% inhibition at 0.006 mM Homo sapiens
1.1.1.62 4'-cyanophenyl 3,4-methylenedioxycinnamate
-
 Homo sapiens
1.1.1.62 4-(octanoylamino)phenyl (2E)-3-phenylprop-2-enoate 15% inhibition at 0.006 mM Homo sapiens
1.1.1.62 4-cyanophenyl (2E)-3-(1,3-benzodioxol-5-yl)prop-2-enoate 76% inhibition at 0.006 mM Homo sapiens
1.1.1.62 6-hydroxyflavone 53.3% inhibition at 0.006 mM Homo sapiens
1.1.1.62 7,4'-Dihydroxyflavone more than 90% inhibition at 0.006 mM Homo sapiens
1.1.1.62 baicalein i.e. 5,6,7-trihydroxyflavone, 61% inhibition at 0.006 mM Homo sapiens
1.1.1.62 benzyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate 60% inhibition at 0.006 mM Homo sapiens
1.1.1.62 benzyl (2E)-3-phenylprop-2-enoate 35% inhibition at 0.006 mM Homo sapiens
1.1.1.62 chrysoeriol i.e. 4',5,7-trihydroxy-3'-methoxyflavone, 82% inhibition at 0.006 mM Homo sapiens
1.1.1.62 Cinnamic acid
-
 Homo sapiens
1.1.1.62 coumarin-3-carboxylic acid
-
 Homo sapiens
1.1.1.62 cyclohexyl (2E)-3-phenylprop-2-enoate 25% inhibition at 0.006 mM Homo sapiens
1.1.1.62 diosmetin i.e. 3',5,7-trihydroxy-4'-methoxyflavone, more than 90% inhibition at 0.006 mM Homo sapiens
1.1.1.62 eupatorin 37% inhibition at 0.006 mM Homo sapiens
1.1.1.62 fisetin 72% inhibition at 0.006 mM Homo sapiens
1.1.1.62 genkwanin 3',5-dihydroxy-7-methoxyflavone, 81% inhibition at 0.006 mM Homo sapiens
1.1.1.62 m-coumaric acid
-
 Homo sapiens
1.1.1.62 myricetin i.e. 3,3',4',5',5,7-hexahydroxyflavone, 52% inhibition at 0.006 mM Homo sapiens
1.1.1.62 naphthalen-2-yl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate 56% inhibition at 0.006 mM Homo sapiens
1.1.1.62 p-aminocinnamic acid
-
 Homo sapiens
1.1.1.62 p-carboxycinnamic acid
-
 Homo sapiens
1.1.1.62 p-nitro-cinnamic acid
-
 Homo sapiens
1.1.1.62 phenyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate 35% inhibition at 0.006 mM Homo sapiens
1.1.1.62 scutellarein i.e. 4',5,6,7-tetrahydroxyflavone, 88% inhibition at 0.006 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens P14061
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 estradiol-17beta + NADP+
-
 Homo sapiens estrone + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.62 17beta-HSD1
-
 Homo sapiens
1.1.1.62 17beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.62 NADP+
-
 Homo sapiens