EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | additional information | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | Mus musculus | |
1.1.1.B40 | additional information | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | Homo sapiens | |
1.1.1.146 | additional information | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | Mus musculus | |
1.1.1.146 | additional information | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | Homo sapiens |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.1.1.B40 | medicine | 11beta-HSD1 is a drug target for treatment of insulin resistance, diabetes and cardiovascular disease | Homo sapiens |
1.1.1.146 | medicine | 11beta-HSD1 is a drug target for treatment of insulin resistance, diabetes and cardiovascular disease | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | - |
Homo sapiens | |
1.1.1.B40 | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | - |
Mus musculus | |
1.1.1.146 | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | - |
Homo sapiens | |
1.1.1.146 | interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 | - |
Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.B40 | corticosterone + NAD+ | Mus musculus | - |
11-dehydrocorticosterone + NADH + H+ | - |
ir | |
1.1.1.B40 | corticosterone + NAD+ | Homo sapiens | - |
11-dehydrocorticosterone + NADH + H+ | - |
ir | |
1.1.1.146 | corticosterone + NADP+ | Mus musculus | - |
11-dehydrocorticosterone + NADPH | - |
ir | |
1.1.1.146 | corticosterone + NADP+ | Homo sapiens | - |
11-dehydrocorticosterone + NADPH | - |
ir | |
1.1.1.146 | cortisone + NADPH + H+ | Mus musculus | - |
cortisol + NADP+ | - |
? | |
1.1.1.146 | cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.B40 | Homo sapiens | - |
- |
- |
1.1.1.B40 | Mus musculus | - |
- |
- |
1.1.1.146 | Homo sapiens | - |
- |
- |
1.1.1.146 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.B40 | adipose tissue | - |
Mus musculus | - |
1.1.1.B40 | adipose tissue | - |
Homo sapiens | - |
1.1.1.B40 | aortic smooth muscle cell | - |
Mus musculus | - |
1.1.1.B40 | aortic smooth muscle cell | - |
Homo sapiens | - |
1.1.1.B40 | colon | - |
Mus musculus | - |
1.1.1.B40 | colon | - |
Homo sapiens | - |
1.1.1.B40 | granulosa cell | - |
Mus musculus | - |
1.1.1.B40 | granulosa cell | - |
Homo sapiens | - |
1.1.1.B40 | liver | - |
Mus musculus | - |
1.1.1.B40 | liver | - |
Homo sapiens | - |
1.1.1.B40 | lung | - |
Mus musculus | - |
1.1.1.B40 | lung | - |
Homo sapiens | - |
1.1.1.B40 | lymph node | peripheral lymph nodes and mesenteric lymph nodes | Mus musculus | - |
1.1.1.B40 | MG-63 cell | - |
Mus musculus | - |
1.1.1.B40 | MG-63 cell | - |
Homo sapiens | - |
1.1.1.146 | adipose tissue | - |
Mus musculus | - |
1.1.1.146 | adipose tissue | - |
Homo sapiens | - |
1.1.1.146 | aortic smooth muscle cell | - |
Mus musculus | - |
1.1.1.146 | aortic smooth muscle cell | - |
Homo sapiens | - |
1.1.1.146 | colon | - |
Mus musculus | - |
1.1.1.146 | colon | - |
Homo sapiens | - |
1.1.1.146 | granulosa cell | - |
Mus musculus | - |
1.1.1.146 | granulosa cell | - |
Homo sapiens | - |
1.1.1.146 | liver | - |
Mus musculus | - |
1.1.1.146 | liver | - |
Homo sapiens | - |
1.1.1.146 | lung | - |
Mus musculus | - |
1.1.1.146 | lung | - |
Homo sapiens | - |
1.1.1.146 | lymph node | peripheral lymph nodes and mesenteric lymph nodes | Mus musculus | - |
1.1.1.146 | MG-63 cell | - |
Mus musculus | - |
1.1.1.146 | MG-63 cell | - |
Homo sapiens | - |
1.1.1.146 | additional information | human monocytes do not express 11beta-HSD1 | Mus musculus | - |
1.1.1.146 | additional information | human monocytes do not express 11beta-HSD1 | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.B40 | corticosterone + NAD+ | - |
Mus musculus | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
1.1.1.B40 | corticosterone + NAD+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADH + H+ | - |
ir | |
1.1.1.146 | corticosterone + NADP+ | - |
Mus musculus | 11-dehydrocorticosterone + NADPH | - |
ir | |
1.1.1.146 | corticosterone + NADP+ | - |
Homo sapiens | 11-dehydrocorticosterone + NADPH | - |
ir | |
1.1.1.146 | cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? | |
1.1.1.146 | cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.B40 | 11beta-HSD2 | - |
Mus musculus |
1.1.1.B40 | 11beta-HSD2 | - |
Homo sapiens |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 2 | - |
Mus musculus |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase type 2 | - |
Homo sapiens |
1.1.1.146 | 11beta-HSD1 | - |
Mus musculus |
1.1.1.146 | 11beta-HSD1 | - |
Homo sapiens |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
1.1.1.146 | 11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.B40 | NAD+ | - |
Mus musculus | |
1.1.1.B40 | NAD+ | - |
Homo sapiens | |
1.1.1.146 | NADP+ | - |
Mus musculus | |
1.1.1.146 | NADP+ | - |
Homo sapiens |