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Literature summary extracted from

  • Chapman, K.E.; Coutinho, A.E.; Gray, M.; Gilmour, J.S.; Savill, J.S.; Seckl, J.R.
    The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response (2009), Mol. Cell. Endocrinol., 301, 123-131.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.B40 additional information interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 Mus musculus
1.1.1.B40 additional information interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 Homo sapiens
1.1.1.146 additional information interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 Mus musculus
1.1.1.146 additional information interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2 Homo sapiens

Application

EC Number Application Comment Organism
1.1.1.B40 medicine 11beta-HSD1 is a drug target for treatment of insulin resistance, diabetes and cardiovascular disease Homo sapiens
1.1.1.146 medicine 11beta-HSD1 is a drug target for treatment of insulin resistance, diabetes and cardiovascular disease Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2
-
Homo sapiens
1.1.1.B40 interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2
-
Mus musculus
1.1.1.146 interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2
-
Homo sapiens
1.1.1.146 interleukin-1beta or tissue necrosis factor-alpha simultaneously increase 11beta-HSD1 expression and down-regulate 11beta-HSD2
-
Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 corticosterone + NAD+ Mus musculus
-
11-dehydrocorticosterone + NADH + H+
-
ir
1.1.1.B40 corticosterone + NAD+ Homo sapiens
-
11-dehydrocorticosterone + NADH + H+
-
ir
1.1.1.146 corticosterone + NADP+ Mus musculus
-
11-dehydrocorticosterone + NADPH
-
ir
1.1.1.146 corticosterone + NADP+ Homo sapiens
-
11-dehydrocorticosterone + NADPH
-
ir
1.1.1.146 cortisone + NADPH + H+ Mus musculus
-
cortisol + NADP+
-
?
1.1.1.146 cortisone + NADPH + H+ Homo sapiens
-
cortisol + NADP+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
-
-
1.1.1.B40 Mus musculus
-
-
-
1.1.1.146 Homo sapiens
-
-
-
1.1.1.146 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 adipose tissue
-
Mus musculus
-
1.1.1.B40 adipose tissue
-
Homo sapiens
-
1.1.1.B40 aortic smooth muscle cell
-
Mus musculus
-
1.1.1.B40 aortic smooth muscle cell
-
Homo sapiens
-
1.1.1.B40 colon
-
Mus musculus
-
1.1.1.B40 colon
-
Homo sapiens
-
1.1.1.B40 granulosa cell
-
Mus musculus
-
1.1.1.B40 granulosa cell
-
Homo sapiens
-
1.1.1.B40 liver
-
Mus musculus
-
1.1.1.B40 liver
-
Homo sapiens
-
1.1.1.B40 lung
-
Mus musculus
-
1.1.1.B40 lung
-
Homo sapiens
-
1.1.1.B40 lymph node peripheral lymph nodes and mesenteric lymph nodes Mus musculus
-
1.1.1.B40 MG-63 cell
-
Mus musculus
-
1.1.1.B40 MG-63 cell
-
Homo sapiens
-
1.1.1.146 adipose tissue
-
Mus musculus
-
1.1.1.146 adipose tissue
-
Homo sapiens
-
1.1.1.146 aortic smooth muscle cell
-
Mus musculus
-
1.1.1.146 aortic smooth muscle cell
-
Homo sapiens
-
1.1.1.146 colon
-
Mus musculus
-
1.1.1.146 colon
-
Homo sapiens
-
1.1.1.146 granulosa cell
-
Mus musculus
-
1.1.1.146 granulosa cell
-
Homo sapiens
-
1.1.1.146 liver
-
Mus musculus
-
1.1.1.146 liver
-
Homo sapiens
-
1.1.1.146 lung
-
Mus musculus
-
1.1.1.146 lung
-
Homo sapiens
-
1.1.1.146 lymph node peripheral lymph nodes and mesenteric lymph nodes Mus musculus
-
1.1.1.146 MG-63 cell
-
Mus musculus
-
1.1.1.146 MG-63 cell
-
Homo sapiens
-
1.1.1.146 additional information human monocytes do not express 11beta-HSD1 Mus musculus
-
1.1.1.146 additional information human monocytes do not express 11beta-HSD1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 corticosterone + NAD+
-
Mus musculus 11-dehydrocorticosterone + NADH + H+
-
ir
1.1.1.B40 corticosterone + NAD+
-
Homo sapiens 11-dehydrocorticosterone + NADH + H+
-
ir
1.1.1.146 corticosterone + NADP+
-
Mus musculus 11-dehydrocorticosterone + NADPH
-
ir
1.1.1.146 corticosterone + NADP+
-
Homo sapiens 11-dehydrocorticosterone + NADPH
-
ir
1.1.1.146 cortisone + NADPH + H+
-
Mus musculus cortisol + NADP+
-
?
1.1.1.146 cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD2
-
Mus musculus
1.1.1.B40 11beta-HSD2
-
Homo sapiens
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
Mus musculus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens
1.1.1.146 11beta-HSD1
-
Mus musculus
1.1.1.146 11beta-HSD1
-
Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
Mus musculus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
Mus musculus
1.1.1.B40 NAD+
-
Homo sapiens
1.1.1.146 NADP+
-
Mus musculus
1.1.1.146 NADP+
-
Homo sapiens