EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.67 | ascorbate | required | Drosophila melanogaster |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.11.67 | overexpression of Flag-tagged Mrg15, CG13367, and Lid in S2 cells | Drosophila melanogaster |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.11.67 | nucleus | Lid-containing protein complex, which is composed of proteins Lid, Rpd3, CG3815/Drosophila Pf1, CG13367, and Mrg15 | Drosophila melanogaster | 5634 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.67 | Fe2+ | required | Drosophila melanogaster |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.67 | additional information | Drosophila melanogaster | the demethylase activity of Lid is not affected by its association with other proteins, but Lid antagonizes Rpd3 function acting as a positive trancription regulator. Lid inhibits the activity of Rpd3 at an Rpd3 target gene | ? | - |
? | |
1.14.11.67 | [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 | Drosophila melanogaster | - |
[histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.67 | Drosophila melanogaster | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.11.67 | embryo | - |
Drosophila melanogaster | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.67 | additional information | the demethylase activity of Lid is not affected by its association with other proteins, but Lid antagonizes Rpd3 function acting as a positive trancription regulator. Lid inhibits the activity of Rpd3 at an Rpd3 target gene | Drosophila melanogaster | ? | - |
? | |
1.14.11.67 | [histone H3]-N6,N6-dimethyl-L-lysine4 + 2 2-oxoglutarate + 2 O2 | - |
Drosophila melanogaster | [histone H3]-L-lysine4 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.14.11.67 | More | Lid is organized in a protein complex, which is composed of proteins Lid, Rpd3, CG3815/Drosophila Pf1, CG13367, and Mrg15, overview | Drosophila melanogaster |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.11.67 | H3K4 demethylase | - |
Drosophila melanogaster |
1.14.11.67 | histone H3 lysine 4 demethylase | - |
Drosophila melanogaster |
1.14.11.67 | Lid | - |
Drosophila melanogaster |
1.14.11.67 | little imaginal discs | - |
Drosophila melanogaster |
1.14.11.67 | More | the enzyme is a Trithorax group protein belonging to the JmjC domain-containing proteins | Drosophila melanogaster |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.14.11.67 | 30 | - |
assay at | Drosophila melanogaster |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.11.67 | 7.9 | - |
assay at | Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.11.67 | physiological function | function of Lid in gene activation, the biochemical activity of this protein entails the removal of a histone mark that is correlated with active transcription | Drosophila melanogaster |