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Literature summary extracted from

  • Pradhan, A.; Mukherjee, P.; Tripathi, A.K.; Avery, M.A.; Walker, L.A.; Tekwani, B.L.
    Analysis of quaternary structure of a [LDH-like] malate dehydrogenase of Plasmodium falciparum with oligomeric mutants (2009), Mol. Cell. Biochem., 325, 141-148.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.37 expressed in Escherichia coli M15 (pREP4) cells Plasmodium falciparum

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.37 R183a dimeric mutant with almost wild type activity Plasmodium falciparum
1.1.1.37 R214G dimeric mutant with almost wild type activity Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.37 0.04954
-
oxaloacetate wild type enzyme Plasmodium falciparum
1.1.1.37 0.04955
-
3-acetylpyridine-adenine dinucleotide wild type enzyme Plasmodium falciparum
1.1.1.37 0.06186
-
oxaloacetate mutant enzyme R214G Plasmodium falciparum
1.1.1.37 0.07238
-
NADH wild type enzyme Plasmodium falciparum
1.1.1.37 0.08074
-
oxaloacetate mutant enzyme R183A Plasmodium falciparum
1.1.1.37 0.0962
-
3-acetylpyridine-adenine dinucleotide mutant enzyme R214G Plasmodium falciparum
1.1.1.37 0.1114
-
3-acetylpyridine-adenine dinucleotide mutant enzyme R183A Plasmodium falciparum
1.1.1.37 0.1197
-
NADH mutant enzyme R214G Plasmodium falciparum
1.1.1.37 0.1231
-
NADH mutant enzyme R183A Plasmodium falciparum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.37 36100
-
4 * 36100, calculated from amino acid sequence Plasmodium falciparum
1.1.1.37 160000
-
enzymatically active preparation of recombinant wild type MDH, calculated from amino acid sequence Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.37 (S)-malate + 3-acetylpyridine-adenine dinucleotide Plasmodium falciparum can also use 3-acetylpyridine-adenine as cofactor oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
-
r
1.1.1.37 (S)-malate + NAD+ Plasmodium falciparum highly specific for oxaloacetate and malate oxaloacetate + NADH + H+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.37 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.37 (S)-malate + 3-acetylpyridine-adenine dinucleotide can also use 3-acetylpyridine-adenine as cofactor Plasmodium falciparum oxaloacetate + reduced 3-acetylpyridine-adenine dinucleotide + H+
-
r
1.1.1.37 (S)-malate + NAD+ highly specific for oxaloacetate and malate Plasmodium falciparum oxaloacetate + NADH + H+
-
r

Subunits

EC Number Subunits Comment Organism
1.1.1.37 homotetramer 4 * 36100, calculated from amino acid sequence Plasmodium falciparum

Synonyms

EC Number Synonyms Comment Organism
1.1.1.37 L-malate dehydrogenase
-
Plasmodium falciparum
1.1.1.37 MDH
-
Plasmodium falciparum
1.1.1.37 [LDH-like] MDH
-
Plasmodium falciparum

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.37 7280
-
3-acetylpyridine-adenine dinucleotide mutant enzyme R183A Plasmodium falciparum
1.1.1.37 7300
-
3-acetylpyridine-adenine dinucleotide wild type enzyme Plasmodium falciparum
1.1.1.37 7500
-
oxaloacetate mutant enzyme R214G Plasmodium falciparum
1.1.1.37 7880
-
NADH wild type enzyme Plasmodium falciparum
1.1.1.37 8320
-
oxaloacetate mutant enzyme R183A Plasmodium falciparum
1.1.1.37 8440
-
NADH mutant enzyme R214G Plasmodium falciparum
1.1.1.37 8570
-
oxaloacetate wild type enzyme Plasmodium falciparum
1.1.1.37 8860
-
NADH mutant enzyme R183A Plasmodium falciparum
1.1.1.37 10050
-
3-acetylpyridine-adenine dinucleotide mutant enzyme R214G Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.37 3-acetylpyridine-adenine dinucleotide
-
Plasmodium falciparum
1.1.1.37 NADH
-
Plasmodium falciparum