Literature summary extracted from

Fornasari, M.S.; Laplagne, D.A.; Frankel, N.; Cauerhff, A.A.; Goldbaum, F.A.; Echave, J.
Sequence determinants of quaternary structure in lumazine synthase (2003), Mol. Biol. Evol., 21, 97-107.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Mesorhizobium loti	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Xanthomonas citri	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Xanthomonas campestris	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Xylella fastidiosa	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Yersinia pestis	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Actinobacillus pleuropneumoniae	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Agrobacterium tumefaciens	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Aquifex aeolicus	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Arabidopsis thaliana	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Archaeoglobus fulgidus	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Bacillus amyloliquefaciens	-	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Halalkalibacterium halodurans	-	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Bacillus subtilis	-	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Bartonella henselae	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Brucella abortus	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Brucella abortus	-	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Buchnera aphidicola	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Campylobacter jejuni	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Caulobacter vibrioides	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Chlamydia muridarum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Chlamydia trachomatis	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Chlorobaculum tepidum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Clostridium perfringens	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Corynebacterium ammoniagenes	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Corynebacterium glutamicum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Sulfurospirillum multivorans	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Deinococcus radiodurans	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Fusobacterium nucleatum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Haemophilus influenzae	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Halobacterium salinarum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Helicobacter pylori J99	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Lactococcus lactis subsp. lactis	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Pyricularia grisea	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Mesorhizobium loti	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Methanocaldococcus jannaschii	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Methanopyrus kandleri	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Methanosarcina acetivorans	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Methanosarcina mazei	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Methanothermobacter thermautotrophicus	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Mycobacterium leprae	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Nicotiana tabacum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Anabaena sp.	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Pasteurella multocida	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Photobacterium leiognathi	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Photobacterium phosphoreum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Pseudomonas aeruginosa	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Pyrobaculum aerophilum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Ralstonia solanacearum	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Rhodococcus erythropolis	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Saccharomyces cerevisiae	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Schizosaccharomyces pombe	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Sinorhizobium meliloti	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Spinacia oleracea	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Streptomyces coelicolor	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Sulfurisphaera tokodaii	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Synechocystis sp.	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Thermotoga maritima	-	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Vibrio cholerae	-	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	Agrobacterium tumefaciens C58 / ATCC 33970	penultimate step of riboflavin biosynthesis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.78	Actinobacillus pleuropneumoniae	P50856	-	-
2.5.1.78	Agrobacterium tumefaciens	Q8UG70	-	-
2.5.1.78	Agrobacterium tumefaciens C58 / ATCC 33970	Q8UG70	-	-
2.5.1.78	Anabaena sp.	Q8YQ43	strain PCC 7120	-
2.5.1.78	Aquifex aeolicus	O66529	-	-
2.5.1.78	Arabidopsis thaliana	O80575	-	-
2.5.1.78	Archaeoglobus fulgidus	O28152	-	-
2.5.1.78	Bacillus amyloliquefaciens	Q44681	-	-
2.5.1.78	Bacillus subtilis	P11998	-	-
2.5.1.78	Bartonella henselae	Q9REF4	-	-
2.5.1.78	Brucella abortus	P61711	-	-
2.5.1.78	Buchnera aphidicola	Q8K9A6	subsp. Schizaphis graminum	-
2.5.1.78	Buchnera aphidicola	Q9ZNM0	subsp. Acyrthosiphon pisum	-
2.5.1.78	Campylobacter jejuni	Q9PIB9	-	-
2.5.1.78	Caulobacter vibrioides	Q9A8J4	-	-
2.5.1.78	Caulobacter vibrioides	Q9A9S4	-	-
2.5.1.78	Chlamydia muridarum	Q9PLJ4	-	-
2.5.1.78	Chlamydia pneumoniae	Q9Z733	-	-
2.5.1.78	Chlamydia trachomatis	O84737	-	-
2.5.1.78	Chlorobaculum tepidum	Q8KAW4	-	-
2.5.1.78	Clostridium acetobutylicum	Q97LG8	-	-
2.5.1.78	Clostridium perfringens	Q8XMW9	-	-
2.5.1.78	Corynebacterium ammoniagenes	O24753	-	-
2.5.1.78	Corynebacterium glutamicum	Q8NQ53	-	-
2.5.1.78	Deinococcus radiodurans	Q9RXZ8	-	-
2.5.1.78	Fusobacterium nucleatum	Q8RIR4	subsp. nucleatum	-
2.5.1.78	Haemophilus influenzae	P45149	-	-
2.5.1.78	Halalkalibacterium halodurans	Q9KCL4	-	-
2.5.1.78	Halobacterium salinarum	Q9HRM5	-	-
2.5.1.78	Helicobacter pylori	O24854	-	-
2.5.1.78	Helicobacter pylori J99	Q9ZN56	-	-
2.5.1.78	Lactococcus lactis subsp. lactis	Q9CGU6	-	-
2.5.1.78	Mesorhizobium loti	Q983B0	-	-
2.5.1.78	Mesorhizobium loti	Q986N2	-	-
2.5.1.78	Methanocaldococcus jannaschii	Q57751	-	-
2.5.1.78	Methanopyrus kandleri	Q8TYL5	-	-
2.5.1.78	Methanosarcina acetivorans	Q8TPT7	-	-
2.5.1.78	Methanosarcina mazei	Q8Q093	-	-
2.5.1.78	Methanothermobacter thermautotrophicus	O27443	-	-
2.5.1.78	Mycobacterium leprae	Q9CCP3	-	-
2.5.1.78	Nicotiana tabacum	Q9XH13	-	-
2.5.1.78	Pasteurella multocida	P57869	-	-
2.5.1.78	Photobacterium leiognathi	Q01994	-	-
2.5.1.78	Photobacterium leiognathi	Q93E92	-	-
2.5.1.78	Photobacterium phosphoreum	P51963	-	-
2.5.1.78	Pseudomonas aeruginosa	Q9HWX5	-	-
2.5.1.78	Pyricularia grisea	Q9UVT8	-	-
2.5.1.78	Pyrobaculum aerophilum	Q8ZTE3	-	-
2.5.1.78	Ralstonia solanacearum	Q8Y1H8	-	-
2.5.1.78	Rhodococcus erythropolis	Q53107	-	-
2.5.1.78	Saccharomyces cerevisiae	P50861	-	-
2.5.1.78	Schizosaccharomyces pombe	Q9UUB1	-	-
2.5.1.78	Sinorhizobium meliloti	Q92NI1	-	-
2.5.1.78	Sinorhizobium meliloti	Q92QU0	-	-
2.5.1.78	Spinacia oleracea	-	-	-
2.5.1.78	Streptomyces coelicolor	Q9EWJ9	-	-
2.5.1.78	Sulfurisphaera tokodaii	Q975M5	-	-
2.5.1.78	Sulfurospirillum multivorans	O68250	-	-
2.5.1.78	Synechocystis sp.	P73527	strain PCC 6803	-
2.5.1.78	Thermotoga maritima	Q9X2E5	-	-
2.5.1.78	Vibrio cholerae	Q9KPU4	-	-
2.5.1.78	Xanthomonas campestris	Q8PCM7	pv. campestris	-
2.5.1.78	Xanthomonas citri	Q8PPD6	-	-
2.5.1.78	Xylella fastidiosa	Q9PES4	-	-
2.5.1.78	Yersinia pestis	Q8ZC41	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Chlamydia muridarum

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Mesorhizobium loti	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Xanthomonas citri	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Xanthomonas campestris	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Xylella fastidiosa	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Yersinia pestis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Actinobacillus pleuropneumoniae	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Agrobacterium tumefaciens	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Aquifex aeolicus	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Arabidopsis thaliana	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Archaeoglobus fulgidus	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	-	Bacillus amyloliquefaciens	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	-	Halalkalibacterium halodurans	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	-	Bacillus subtilis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Bartonella henselae	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Brucella abortus	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	-	Brucella abortus	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Buchnera aphidicola	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Campylobacter jejuni	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Caulobacter vibrioides	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Chlamydia muridarum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Chlamydia trachomatis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Chlorobaculum tepidum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Clostridium perfringens	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Corynebacterium ammoniagenes	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Corynebacterium glutamicum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Sulfurospirillum multivorans	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Deinococcus radiodurans	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Fusobacterium nucleatum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Haemophilus influenzae	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Halobacterium salinarum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Helicobacter pylori J99	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Lactococcus lactis subsp. lactis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Pyricularia grisea	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Mesorhizobium loti	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Methanocaldococcus jannaschii	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Methanopyrus kandleri	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Methanosarcina acetivorans	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Methanosarcina mazei	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Methanothermobacter thermautotrophicus	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Mycobacterium leprae	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Nicotiana tabacum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Anabaena sp.	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Pasteurella multocida	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Photobacterium leiognathi	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Photobacterium phosphoreum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Pseudomonas aeruginosa	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Pyrobaculum aerophilum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Ralstonia solanacearum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Rhodococcus erythropolis	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Saccharomyces cerevisiae	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Schizosaccharomyces pombe	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Sinorhizobium meliloti	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Spinacia oleracea	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Streptomyces coelicolor	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Sulfurisphaera tokodaii	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Synechocystis sp.	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	-	Thermotoga maritima	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	-	Vibrio cholerae	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Clostridium acetobutylicum	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Helicobacter pylori	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?
2.5.1.78	5-amino-6-(1-D-ribitylamino)pyrimidine-2,4(1H,3H)-dione + (S)-2-hydroxy-3-oxobutyl dihydrogen phosphate	penultimate step of riboflavin biosynthesis	Agrobacterium tumefaciens C58 / ATCC 33970	6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O	-	?

Subunits

EC Number	Subunits	Comment	Organism
2.5.1.78	60-mer	sequence determinants responsible for the icosahedral quaternary structure	Aquifex aeolicus
2.5.1.78	60-mer	sequence determinants responsible for the icosahedral quaternary structure	Bacillus subtilis
2.5.1.78	60-mer	sequence determinants responsible for the icosahedral quaternary structure	Spinacia oleracea
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Xanthomonas citri
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Xanthomonas campestris
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Xylella fastidiosa
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Yersinia pestis
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Actinobacillus pleuropneumoniae
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Agrobacterium tumefaciens
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Aquifex aeolicus
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Arabidopsis thaliana
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Archaeoglobus fulgidus
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Bacillus amyloliquefaciens
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Halalkalibacterium halodurans
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Bacillus subtilis
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Bartonella henselae
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Brucella abortus
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Buchnera aphidicola
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Campylobacter jejuni
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Caulobacter vibrioides
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Chlamydia trachomatis
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Chlamydia pneumoniae
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Chlorobaculum tepidum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Clostridium acetobutylicum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Clostridium perfringens
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Corynebacterium ammoniagenes
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Corynebacterium glutamicum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Sulfurospirillum multivorans
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Deinococcus radiodurans
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Fusobacterium nucleatum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Haemophilus influenzae
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Halobacterium salinarum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Helicobacter pylori
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Helicobacter pylori J99
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Lactococcus lactis subsp. lactis
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Pyricularia grisea
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Mesorhizobium loti
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Methanocaldococcus jannaschii
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Methanopyrus kandleri
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Methanosarcina acetivorans
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Methanosarcina mazei
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Methanothermobacter thermautotrophicus
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Mycobacterium leprae
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Nicotiana tabacum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Anabaena sp.
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Pasteurella multocida
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Photobacterium leiognathi
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Photobacterium phosphoreum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Pseudomonas aeruginosa
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Pyrobaculum aerophilum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Ralstonia solanacearum
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Rhodococcus erythropolis
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Saccharomyces cerevisiae
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Schizosaccharomyces pombe
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Sinorhizobium meliloti
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Spinacia oleracea
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Streptomyces coelicolor
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Sulfurisphaera tokodaii
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Synechocystis sp.
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Thermotoga maritima
2.5.1.78	additional information	lumazine synthase is found in different species in two different quaternary structures, pentameric and icosahedral, built from practically the same structural monomeric unit. The icosahedral structure is best described as a capsid of twelve pentamers. Despite this noticeable difference, the active sites are virtually identical in all structurally studied members. The main regions involved in the catalysis are located at the interface between adjacent subunits in the pentamer. Combined analysis that includes sequence-structure and evolutionary studies to find the sequence determinants of the different quaternary assemblies of this enzyme. The positions involved in icosahedral contacts suffer a larger increase in constraints than the rest. Eight sequence sites that would be the most important icosahedral sequence determinants are identified	Vibrio cholerae
2.5.1.78	pentamer	-	Brucella abortus
2.5.1.78	pentamer	-	Pyricularia grisea
2.5.1.78	pentamer	-	Saccharomyces cerevisiae
2.5.1.78	pentamer	-	Schizosaccharomyces pombe

Synonyms

EC Number	Synonyms	Comment	Organism
2.5.1.78	6,7-dimethyl-8-ribityllumazine synthase 1	-	Mesorhizobium loti
2.5.1.78	6,7-dimethyl-8-ribityllumazine synthase 1	-	Sinorhizobium meliloti
2.5.1.78	6,7-dimethyl-8-ribityllumazine synthase 2	-	Mesorhizobium loti
2.5.1.78	6,7-dimethyl-8-ribityllumazine synthase 2	-	Sinorhizobium meliloti
2.5.1.78	lumazine synthase 1	-	Caulobacter vibrioides
2.5.1.78	lumazine synthase 1	-	Sinorhizobium meliloti
2.5.1.78	lumazine synthase 2	-	Caulobacter vibrioides
2.5.1.78	lumazine synthase 2	-	Sinorhizobium meliloti
2.5.1.78	RibH	-	Actinobacillus pleuropneumoniae
2.5.1.78	ribH1	-	Caulobacter vibrioides
2.5.1.78	ribH1	-	Sinorhizobium meliloti
2.5.1.78	RibH2	-	Caulobacter vibrioides
2.5.1.78	RibH2	-	Sinorhizobium meliloti