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Literature summary extracted from

  • Messerli, S.M.; Kasinathan, R.S.; Morgan, W.; Spranger, S.; Greenberg, R.M.
    Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibility (2009), Mol. Biochem. Parasitol., 167, 54-59.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.2 additional information praziquantel, a drug used against schistosomiasis, transiently induces expression of SMDR2 in adult worms Schistosoma mansoni

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2 SMDR2, expression analysis Schistosoma mansoni

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.6.2.2 Mg2+
-
 Schistosoma mansoni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 ATP + H2O + xenobiotic/in Schistosoma mansoni SMDR2 is an ATP-dependent efflux pump involved in transport of toxins and xenobiotics from cells ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 additional information Schistosoma mansoni adult worms from the Egyptian Schistosoma mansoni isolate with reduced sensitivity to praziquantel express increased levels of SMDR2 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Schistosoma mansoni
-
 SMDR2, Egyptian isolate propagated in female Swiss Webster mice
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + xenobiotic/in
-
 Schistosoma mansoni ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 ATP + H2O + xenobiotic/in SMDR2 is an ATP-dependent efflux pump involved in transport of toxins and xenobiotics from cells Schistosoma mansoni ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 additional information adult worms from the Egyptian Schistosoma mansoni isolate with reduced sensitivity to praziquantel express increased levels of SMDR2 Schistosoma mansoni ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 More P-glycoprotein is a member of the ATP-binding-cassette superfamily of proteins Schistosoma mansoni
7.6.2.2 P-glycoprotein
-
 Schistosoma mansoni
7.6.2.2 SMDR2
-
 Schistosoma mansoni

Cofactor

EC Number Cofactor Comment Organism Structure
7.6.2.2 ATP
-
 Schistosoma mansoni