Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Oura, T.; Kajiwara, S.
    Disruption of the sphingolipid DELTA8-desaturase gene causes a delay in morphological changes in Candida albicans (2008), Microbiology, 154, 3795-3803.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.4 into pBluescript II SK+ and subsequently into pFLAG-Act1 Candida albicans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.18 (4E)-sphing-4-enine ceramide + ferrocytochrome b5 + O2 + H+ Candida albicans
-
 (4E,8E)-sphing-4,8-dienine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.18 (4E)-sphing-4-enine ceramide + ferrocytochrome b5 + O2 + H+ Candida albicans TUA6
-
 (4E,8E)-sphing-4,8-dienine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.29 (E)-sphing-4-enine + ferrocytochrome b5 + O2 + H+ Candida albicans
-
 (4E,8E)-sphinga-4,8-dienine + ferricytochrome b5 + H2O
-
 ?
1.14.19.29 (E)-sphing-4-enine + ferrocytochrome b5 + O2 + H+ Candida albicans TUA6
-
 (4E,8E)-sphinga-4,8-dienine + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.4 Candida albicans
-
-
-
1.14.19.18 Candida albicans
-
-
-
1.14.19.29 Candida albicans
-
-
-
1.14.19.29 Candida albicans TUA6
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.4 (E)-sphing-4-enine + reduced acceptor + O2
-
 Candida albicans (2S,3R,4E,8E)-2-aminooctadeca-4,8-diene-1,3-diol + acceptor + H2O
-
 ?
1.14.19.4 (E)-sphing-4-enine + reduced acceptor + O2
-
 Candida albicans TUA6 (2S,3R,4E,8E)-2-aminooctadeca-4,8-diene-1,3-diol + acceptor + H2O
-
 ?
1.14.19.18 (4E)-sphing-4-enine ceramide + ferrocytochrome b5 + O2 + H+
-
 Candida albicans (4E,8E)-sphing-4,8-dienine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.18 (4E)-sphing-4-enine ceramide + ferrocytochrome b5 + O2 + H+
-
 Candida albicans TUA6 (4E,8E)-sphing-4,8-dienine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.29 (E)-sphing-4-enine + ferrocytochrome b5 + O2 + H+
-
 Candida albicans (4E,8E)-sphinga-4,8-dienine + ferricytochrome b5 + H2O
-
 ?
1.14.19.29 (E)-sphing-4-enine + ferrocytochrome b5 + O2 + H+
-
 Candida albicans TUA6 (4E,8E)-sphinga-4,8-dienine + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.4 Ca-SLDp
-
 Candida albicans
1.14.19.4 SLD
-
 Candida albicans
1.14.19.4 sphingolipid DELTA8-desaturase
-
 Candida albicans
1.14.19.18 DELTA8-sphingolipid desaturase
-
 Candida albicans
1.14.19.18 SLD
-
 Candida albicans
1.14.19.29 SLD
-
 Candida albicans
1.14.19.29 sphingolipid DELTA8-desaturase
-
 Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.18 cytochrome b5
-
 Candida albicans

General Information

EC Number General Information Comment Organism
1.14.19.18 physiological function disruption of the DELTA8-sphingolipid desaturase gene leads to a decreased hyphal growth rate compared with the wild type strain Candida albicans
1.14.19.29 malfunction gene disruption leads to a decreased hyphal growth rate and increased sensitivity against SDS compared with the wild type strain Candida albicans