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Literature summary extracted from

  • Mills, P.C.; Rowley, G.; Spiro, S.; Hinton, J.C.; Richardson, D.J.
    A combination of cytochrome c nitrite reductase (NrfA) and flavorubredoxin (NorV) protects Salmonella enterica serovar Typhimurium against killing by NO in anoxic environments (2008), Microbiology, 154, 1218-1228.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.7.2.2 additional information effects of all eight possible combinations of norV, hmpA and nrfA single, double and triple mutations, overview. The norV nrfA mutant cannot grow after NO addition Salmonella enterica

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.7.2.2 NO wild-type cultures are more sensitive to the addition of a pulse of NO when grown under fermentative conditions compared with anaerobic respiratory conditions, sensitivity of different wild-type and mutant strains, overview Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.7.2.2 nitrite + ferrocytochrome c + H+ Salmonella enterica protection against NO may involve reductive detoxification in low-oxygen environments, and three enzymes, flavorubredoxin, flavohaemoglobin and cytochrome c nitrite reductase: Determination of a combined role for NorV and NrfA in NO detoxification under anaerobic conditions, overview NH3 + H2O + ferricytochrome c
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.7.2.2 Salmonella enterica
-
 serovar typhimurium
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.7.2.2 nitrite + ferrocytochrome c + H+
-
 Salmonella enterica NH3 + H2O + ferricytochrome c
-
 ?
1.7.2.2 nitrite + ferrocytochrome c + H+ protection against NO may involve reductive detoxification in low-oxygen environments, and three enzymes, flavorubredoxin, flavohaemoglobin and cytochrome c nitrite reductase: Determination of a combined role for NorV and NrfA in NO detoxification under anaerobic conditions, overview Salmonella enterica NH3 + H2O + ferricytochrome c
-
 ?
1.7.2.2 nitrite + reduced methyl viologen
-
 Salmonella enterica NH3 + H2O + oxidized methyl viologen
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.7.2.2 cytochrome c nitrite reductase
-
 Salmonella enterica
1.7.2.2 NrfA
-
 Salmonella enterica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.7.2.2 7.5
-
 assay at Salmonella enterica

Cofactor

EC Number Cofactor Comment Organism Structure
1.7.2.2 methyl viologen artificial cofactor Salmonella enterica