Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Valvano, M.A.; Messner, P.; Kosma, P.
    Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides (2002), Microbiology, 148, 1979-1989.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.167 55000
-
x * 55000, SDS-PAGE Escherichia coli
2.7.7.70 55000
-
x * 55000, SDS-PAGE Escherichia coli
5.3.1.28 29000
-
2 * 29000, SDS-PAGE Escherichia coli
5.3.1.28 60000 80000 gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.167 D-glycero-D-manno-heptose 7-phosphate + ATP Escherichia coli
-
D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP
-
?
2.7.1.168 D-glycero-alpha-D-manno-heptose 7-phosphate + ATP Aneurinibacillus thermoaerophilus
-
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP
-
?
2.7.7.70 D-glycero-beta-D-manno-heptose 1-phosphate + ATP Escherichia coli
-
ADP-D-glycero-beta-D-manno-heptose + diphosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O Helicobacter pylori
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O Neisseria meningitidis
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O Pseudomonas aeruginosa
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O Vibrio cholerae
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O Clostridium acetobutylicum
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O [Haemophilus] ducreyi
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O Haemophilus influenzae
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O Helicobacter pylori J99
-
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.83 D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O Aneurinibacillus thermoaerophilus
-
D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Clostridium acetobutylicum
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Haemophilus influenzae
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Helicobacter pylori J99
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Mycobacterium tuberculosis
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Neisseria meningitidis
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Pseudomonas aeruginosa
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Salmonella enterica subsp. enterica serovar Typhimurium
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Vibrio cholerae
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Yersinia pestis
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Escherichia coli
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Aneurinibacillus thermoaerophilus
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Campylobacter jejuni
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Burkholderia mallei
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Burkholderia pseudomallei
-
D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate Mycobacterium tuberculosis H37Rv
-
D-glycero-D-manno-heptose 7-phosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.167 Escherichia coli
-
-
-
2.7.1.168 Aneurinibacillus thermoaerophilus Q9AGY8 DSM 10155
-
2.7.7.70 Escherichia coli
-
-
-
3.1.3.82 Clostridium acetobutylicum Q97EQ5
-
-
3.1.3.82 Haemophilus influenzae P46452
-
-
3.1.3.82 Helicobacter pylori O25531
-
-
3.1.3.82 Helicobacter pylori J99 Q9ZKY8
-
-
3.1.3.82 Neisseria meningitidis Q9JWE9 serogroup A
-
3.1.3.82 Pseudomonas aeruginosa Q9I7C0
-
-
3.1.3.82 Salmonella enterica subsp. enterica serovar Typhimurium Q8ZRM8
-
-
3.1.3.82 Vibrio cholerae Q9KTJ4
-
-
3.1.3.82 [Haemophilus] ducreyi Q7VL21
-
-
3.1.3.83 Aneurinibacillus thermoaerophilus Q9AGY5
-
-
5.3.1.28 Aneurinibacillus thermoaerophilus Q9AGY7
-
-
5.3.1.28 Burkholderia mallei Q9AI36
-
-
5.3.1.28 Burkholderia pseudomallei Q93UJ2
-
-
5.3.1.28 Campylobacter jejuni Q9PMN3
-
-
5.3.1.28 Campylobacter jejuni Q9PNE6
-
-
5.3.1.28 Clostridium acetobutylicum Q97EQ4
-
-
5.3.1.28 Escherichia coli P63224
-
-
5.3.1.28 Haemophilus influenzae P45093
-
-
5.3.1.28 Helicobacter pylori J99 Q9ZKZ1
-
-
5.3.1.28 Mycobacterium tuberculosis P9WGG1
-
-
5.3.1.28 Mycobacterium tuberculosis H37Rv P9WGG1
-
-
5.3.1.28 Neisseria meningitidis P0A0Y5 serogroup A
-
5.3.1.28 Neisseria meningitidis P0A0Y6 serogroup B
-
5.3.1.28 Pseudomonas aeruginosa Q9HVZ0
-
-
5.3.1.28 Salmonella enterica subsp. enterica serovar Typhimurium P63223
-
-
5.3.1.28 Vibrio cholerae Q9KPY2
-
-
5.3.1.28 Yersinia pestis Q8ZBY7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.167 D-glycero-D-manno-heptose 7-phosphate + ATP
-
Escherichia coli D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP
-
?
2.7.1.167 D-glycero-D-manno-heptose 7-phosphate + ATP bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-D-heptose-1-phosphate adenylyltransferase. Based on genomic sequence comparisons, bifunctional proteins are predicted to be present in several Gram-negative microorganisms, including Agrobacterium tumefaciens, Buchnera sp., Caulobacter crescentus, Salmonella typhimurium, Salmonella typhi, Vibrio cholerae, Yersinia pestis, Haemophilus influenzae, Helicobacter pylori and Pseudomonas aeruginosa. In contrast, individual genes encoding domains I and II independently are found in Ralstonia eutropha, Neisseria meningitidis and Neisseria gonorrhoeae. In these cases, it is proposed to use the nomenclature hldA and hldC to indicate the individual kinase- and adenylyltransferase-encoding genes, respectively Escherichia coli D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP
-
?
2.7.1.168 D-glycero-alpha-D-manno-heptose 7-phosphate + ATP
-
Aneurinibacillus thermoaerophilus D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP
-
?
2.7.1.168 D-glycero-alpha-D-manno-heptose 7-phosphate + ATP the enzyme is specific for alpha anomer Aneurinibacillus thermoaerophilus D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP
-
?
2.7.7.70 D-glycero-beta-D-manno-heptose 1-phosphate + ATP
-
Escherichia coli ADP-D-glycero-beta-D-manno-heptose + diphosphate
-
?
2.7.7.70 D-glycero-beta-D-manno-heptose 1-phosphate + ATP bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase. Based on genomic sequence comparisons, bifunctional proteins are predicted to be present in several Gram-negative microorganisms, including Agrobacterium tumefaciens, Buchnera sp., Caulobacter crescentus, Salmonella typhimurium, Salmonella typhi, Vibrio cholerae, Yersinia pestis, Haemophilus influenzae, Helicobacter pylori and Pseudomonas aeruginosa. In contrast, individual genes encoding domains I and II independently are found in Ralstonia eutropha, Neisseria meningitidis and Neisseria gonorrhoeae. In these cases, it is proposed to use the nomenclature hldA and hldC to indicate the individual kinase- and adenylyltransferase-encoding genes, respectively Escherichia coli ADP-D-glycero-beta-D-manno-heptose + diphosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
Helicobacter pylori D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
Neisseria meningitidis D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
Pseudomonas aeruginosa D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
Vibrio cholerae D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
Clostridium acetobutylicum D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
[Haemophilus] ducreyi D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
Haemophilus influenzae D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O
-
Helicobacter pylori J99 D-glycero-beta-D-manno-heptose 1-phosphate + phosphate
-
?
3.1.3.83 D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O
-
Aneurinibacillus thermoaerophilus D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Clostridium acetobutylicum D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Haemophilus influenzae D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Helicobacter pylori J99 D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Mycobacterium tuberculosis D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Neisseria meningitidis D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Pseudomonas aeruginosa D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Vibrio cholerae D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Yersinia pestis D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Escherichia coli D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Aneurinibacillus thermoaerophilus D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Campylobacter jejuni D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Burkholderia mallei D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Burkholderia pseudomallei D-glycero-D-manno-heptose 7-phosphate
-
?
5.3.1.28 D-sedoheptulose 7-phosphate
-
Mycobacterium tuberculosis H37Rv D-glycero-D-manno-heptose 7-phosphate
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.167 ? x * 55000, SDS-PAGE Escherichia coli
2.7.1.167 More the N-terminal domain I spans amino acids 1-318 and shares structural features with members of the ribokinase family. The C-terminal domain II, which spans amino acids 344-477, has all the conserved features of the cytidylyltransferase superfamily Escherichia coli
2.7.7.70 ? x * 55000, SDS-PAGE Escherichia coli
2.7.7.70 More the N-terminal domain I spans amino acids 1-318 and shares structural features with members of the ribokinase family. The C-terminal domain II, which spans amino acids 344-477, has all the conserved features of the cytidylyltransferase superfamily Escherichia coli
5.3.1.28 dimer 2 * 29000, SDS-PAGE Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.7.1.167 bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase
-
Escherichia coli
2.7.7.70 bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase
-
Escherichia coli
3.1.3.82 D-heptose-1,7-bisphosphate phosphatase
-
Clostridium acetobutylicum
3.1.3.83 D-heptose-1,7-bisphosphate phosphatase
-
Aneurinibacillus thermoaerophilus
5.3.1.28 phosphoheptose isomerase
-
Clostridium acetobutylicum
5.3.1.28 phosphoheptose isomerase
-
Haemophilus influenzae
5.3.1.28 phosphoheptose isomerase
-
Helicobacter pylori J99
5.3.1.28 phosphoheptose isomerase
-
Mycobacterium tuberculosis
5.3.1.28 phosphoheptose isomerase
-
Neisseria meningitidis
5.3.1.28 phosphoheptose isomerase
-
Pseudomonas aeruginosa
5.3.1.28 phosphoheptose isomerase
-
Salmonella enterica subsp. enterica serovar Typhimurium
5.3.1.28 phosphoheptose isomerase
-
Vibrio cholerae
5.3.1.28 phosphoheptose isomerase
-
Yersinia pestis
5.3.1.28 phosphoheptose isomerase
-
Escherichia coli
5.3.1.28 phosphoheptose isomerase
-
Aneurinibacillus thermoaerophilus
5.3.1.28 phosphoheptose isomerase
-
Campylobacter jejuni
5.3.1.28 phosphoheptose isomerase
-
Burkholderia mallei
5.3.1.28 phosphoheptose isomerase
-
Burkholderia pseudomallei