EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.1.167 | 55000 | - |
x * 55000, SDS-PAGE | Escherichia coli |
2.7.7.70 | 55000 | - |
x * 55000, SDS-PAGE | Escherichia coli |
5.3.1.28 | 29000 | - |
2 * 29000, SDS-PAGE | Escherichia coli |
5.3.1.28 | 60000 | 80000 | gel filtration | Escherichia coli |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.167 | D-glycero-D-manno-heptose 7-phosphate + ATP | Escherichia coli | - |
D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP | - |
? | |
2.7.1.168 | D-glycero-alpha-D-manno-heptose 7-phosphate + ATP | Aneurinibacillus thermoaerophilus | - |
D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP | - |
? | |
2.7.7.70 | D-glycero-beta-D-manno-heptose 1-phosphate + ATP | Escherichia coli | - |
ADP-D-glycero-beta-D-manno-heptose + diphosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | Helicobacter pylori | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | Neisseria meningitidis | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | Pseudomonas aeruginosa | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | Vibrio cholerae | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | Clostridium acetobutylicum | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | [Haemophilus] ducreyi | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | Haemophilus influenzae | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | Helicobacter pylori J99 | - |
D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.83 | D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O | Aneurinibacillus thermoaerophilus | - |
D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Clostridium acetobutylicum | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Haemophilus influenzae | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Helicobacter pylori J99 | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Mycobacterium tuberculosis | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Neisseria meningitidis | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Pseudomonas aeruginosa | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Salmonella enterica subsp. enterica serovar Typhimurium | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Vibrio cholerae | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Yersinia pestis | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Escherichia coli | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Aneurinibacillus thermoaerophilus | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Campylobacter jejuni | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Burkholderia mallei | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Burkholderia pseudomallei | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | Mycobacterium tuberculosis H37Rv | - |
D-glycero-D-manno-heptose 7-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.167 | Escherichia coli | - |
- |
- |
2.7.1.168 | Aneurinibacillus thermoaerophilus | Q9AGY8 | DSM 10155 | - |
2.7.7.70 | Escherichia coli | - |
- |
- |
3.1.3.82 | Clostridium acetobutylicum | Q97EQ5 | - |
- |
3.1.3.82 | Haemophilus influenzae | P46452 | - |
- |
3.1.3.82 | Helicobacter pylori | O25531 | - |
- |
3.1.3.82 | Helicobacter pylori J99 | Q9ZKY8 | - |
- |
3.1.3.82 | Neisseria meningitidis | Q9JWE9 | serogroup A | - |
3.1.3.82 | Pseudomonas aeruginosa | Q9I7C0 | - |
- |
3.1.3.82 | Salmonella enterica subsp. enterica serovar Typhimurium | Q8ZRM8 | - |
- |
3.1.3.82 | Vibrio cholerae | Q9KTJ4 | - |
- |
3.1.3.82 | [Haemophilus] ducreyi | Q7VL21 | - |
- |
3.1.3.83 | Aneurinibacillus thermoaerophilus | Q9AGY5 | - |
- |
5.3.1.28 | Aneurinibacillus thermoaerophilus | Q9AGY7 | - |
- |
5.3.1.28 | Burkholderia mallei | Q9AI36 | - |
- |
5.3.1.28 | Burkholderia pseudomallei | Q93UJ2 | - |
- |
5.3.1.28 | Campylobacter jejuni | Q9PMN3 | - |
- |
5.3.1.28 | Campylobacter jejuni | Q9PNE6 | - |
- |
5.3.1.28 | Clostridium acetobutylicum | Q97EQ4 | - |
- |
5.3.1.28 | Escherichia coli | P63224 | - |
- |
5.3.1.28 | Haemophilus influenzae | P45093 | - |
- |
5.3.1.28 | Helicobacter pylori J99 | Q9ZKZ1 | - |
- |
5.3.1.28 | Mycobacterium tuberculosis | P9WGG1 | - |
- |
5.3.1.28 | Mycobacterium tuberculosis H37Rv | P9WGG1 | - |
- |
5.3.1.28 | Neisseria meningitidis | P0A0Y5 | serogroup A | - |
5.3.1.28 | Neisseria meningitidis | P0A0Y6 | serogroup B | - |
5.3.1.28 | Pseudomonas aeruginosa | Q9HVZ0 | - |
- |
5.3.1.28 | Salmonella enterica subsp. enterica serovar Typhimurium | P63223 | - |
- |
5.3.1.28 | Vibrio cholerae | Q9KPY2 | - |
- |
5.3.1.28 | Yersinia pestis | Q8ZBY7 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.167 | D-glycero-D-manno-heptose 7-phosphate + ATP | - |
Escherichia coli | D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP | - |
? | |
2.7.1.167 | D-glycero-D-manno-heptose 7-phosphate + ATP | bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-D-heptose-1-phosphate adenylyltransferase. Based on genomic sequence comparisons, bifunctional proteins are predicted to be present in several Gram-negative microorganisms, including Agrobacterium tumefaciens, Buchnera sp., Caulobacter crescentus, Salmonella typhimurium, Salmonella typhi, Vibrio cholerae, Yersinia pestis, Haemophilus influenzae, Helicobacter pylori and Pseudomonas aeruginosa. In contrast, individual genes encoding domains I and II independently are found in Ralstonia eutropha, Neisseria meningitidis and Neisseria gonorrhoeae. In these cases, it is proposed to use the nomenclature hldA and hldC to indicate the individual kinase- and adenylyltransferase-encoding genes, respectively | Escherichia coli | D-glycero-beta-D-mannoheptose 1,7-bisphosphate + ADP | - |
? | |
2.7.1.168 | D-glycero-alpha-D-manno-heptose 7-phosphate + ATP | - |
Aneurinibacillus thermoaerophilus | D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP | - |
? | |
2.7.1.168 | D-glycero-alpha-D-manno-heptose 7-phosphate + ATP | the enzyme is specific for alpha anomer | Aneurinibacillus thermoaerophilus | D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP | - |
? | |
2.7.7.70 | D-glycero-beta-D-manno-heptose 1-phosphate + ATP | - |
Escherichia coli | ADP-D-glycero-beta-D-manno-heptose + diphosphate | - |
? | |
2.7.7.70 | D-glycero-beta-D-manno-heptose 1-phosphate + ATP | bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase. Based on genomic sequence comparisons, bifunctional proteins are predicted to be present in several Gram-negative microorganisms, including Agrobacterium tumefaciens, Buchnera sp., Caulobacter crescentus, Salmonella typhimurium, Salmonella typhi, Vibrio cholerae, Yersinia pestis, Haemophilus influenzae, Helicobacter pylori and Pseudomonas aeruginosa. In contrast, individual genes encoding domains I and II independently are found in Ralstonia eutropha, Neisseria meningitidis and Neisseria gonorrhoeae. In these cases, it is proposed to use the nomenclature hldA and hldC to indicate the individual kinase- and adenylyltransferase-encoding genes, respectively | Escherichia coli | ADP-D-glycero-beta-D-manno-heptose + diphosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
Helicobacter pylori | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
Neisseria meningitidis | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
Pseudomonas aeruginosa | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
Vibrio cholerae | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
Clostridium acetobutylicum | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
[Haemophilus] ducreyi | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
Haemophilus influenzae | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.82 | D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H2O | - |
Helicobacter pylori J99 | D-glycero-beta-D-manno-heptose 1-phosphate + phosphate | - |
? | |
3.1.3.83 | D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + H2O | - |
Aneurinibacillus thermoaerophilus | D-glycero-alpha-D-manno-heptose 1-phosphate + phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Clostridium acetobutylicum | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Haemophilus influenzae | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Helicobacter pylori J99 | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Mycobacterium tuberculosis | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Neisseria meningitidis | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Pseudomonas aeruginosa | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Vibrio cholerae | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Yersinia pestis | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Escherichia coli | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Aneurinibacillus thermoaerophilus | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Campylobacter jejuni | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Burkholderia mallei | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Burkholderia pseudomallei | D-glycero-D-manno-heptose 7-phosphate | - |
? | |
5.3.1.28 | D-sedoheptulose 7-phosphate | - |
Mycobacterium tuberculosis H37Rv | D-glycero-D-manno-heptose 7-phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.167 | ? | x * 55000, SDS-PAGE | Escherichia coli |
2.7.1.167 | More | the N-terminal domain I spans amino acids 1-318 and shares structural features with members of the ribokinase family. The C-terminal domain II, which spans amino acids 344-477, has all the conserved features of the cytidylyltransferase superfamily | Escherichia coli |
2.7.7.70 | ? | x * 55000, SDS-PAGE | Escherichia coli |
2.7.7.70 | More | the N-terminal domain I spans amino acids 1-318 and shares structural features with members of the ribokinase family. The C-terminal domain II, which spans amino acids 344-477, has all the conserved features of the cytidylyltransferase superfamily | Escherichia coli |
5.3.1.28 | dimer | 2 * 29000, SDS-PAGE | Escherichia coli |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.167 | bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase | - |
Escherichia coli |
2.7.7.70 | bifunctional D-beta-D-heptose-7-phosphate kinase/D-beta-dheptose-1-phosphate adenylyltransferase | - |
Escherichia coli |
3.1.3.82 | D-heptose-1,7-bisphosphate phosphatase | - |
Clostridium acetobutylicum |
3.1.3.83 | D-heptose-1,7-bisphosphate phosphatase | - |
Aneurinibacillus thermoaerophilus |
5.3.1.28 | phosphoheptose isomerase | - |
Clostridium acetobutylicum |
5.3.1.28 | phosphoheptose isomerase | - |
Haemophilus influenzae |
5.3.1.28 | phosphoheptose isomerase | - |
Helicobacter pylori J99 |
5.3.1.28 | phosphoheptose isomerase | - |
Mycobacterium tuberculosis |
5.3.1.28 | phosphoheptose isomerase | - |
Neisseria meningitidis |
5.3.1.28 | phosphoheptose isomerase | - |
Pseudomonas aeruginosa |
5.3.1.28 | phosphoheptose isomerase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
5.3.1.28 | phosphoheptose isomerase | - |
Vibrio cholerae |
5.3.1.28 | phosphoheptose isomerase | - |
Yersinia pestis |
5.3.1.28 | phosphoheptose isomerase | - |
Escherichia coli |
5.3.1.28 | phosphoheptose isomerase | - |
Aneurinibacillus thermoaerophilus |
5.3.1.28 | phosphoheptose isomerase | - |
Campylobacter jejuni |
5.3.1.28 | phosphoheptose isomerase | - |
Burkholderia mallei |
5.3.1.28 | phosphoheptose isomerase | - |
Burkholderia pseudomallei |