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Literature summary extracted from

  • Haseba, T.; Sugimoto, J.; Sato, S.; Abe, Y.; Ohno, Y.
    Phytophenols in whisky lower blood acetaldehyde level by depressing alcohol metabolism through inhibition of alcohol dehydrogenase 1 (class I) in mice (2008), Metab. Clin. Exp., 57, 1753-1759.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.1 caffeic acid mixed type of inhibition Mus musculus
1.1.1.1 ellagic acid mixed type of inhibition Mus musculus
1.1.1.1 pyrazole
-
 Mus musculus
1.1.1.1 syringaldehyde mixed type of inhibition Mus musculus
1.1.1.1 Vanillin mixed type of inhibition Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.1 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 ethanol + NAD+
-
 Mus musculus acetaldehyde + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.1 ADH 1
-
 Mus musculus
1.1.1.1 alcohol dehydrogenase 1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.1 NAD+
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.1 0.00008
-
 caffeic acid at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus
1.1.1.1 0.0051
-
 pyrazole at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus
1.1.1.1 0.0079
-
 Vanillin at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus
1.1.1.1 0.0156
-
 syringaldehyde at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus
1.1.1.1 0.022
-
 ellagic acid at 37°C in 0.1 M Na-K phosphate buffer (pH 7.4) Mus musculus