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Literature summary extracted from

  • Mora-Montes, H.M.; Lopez-Romero, E.; Zinker, S.; Ponce-Noyola, P.; Flores-Carreon, A.
    Heterologous expression and biochemical characterization of an alpha1,2-mannosidase encoded by the Candida albicans MNS1 gene (2008), Mem. Inst. Oswaldo Cruz, 103, 724-730.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.1.209 expression in Escherichia coli Candida albicans

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.209 1-deoxymannojirimycin
-
 Candida albicans
3.2.1.209 swainsonine
-
 Candida albicans

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.209 0.07
-
 4-methylumbelliferyl-alpha-D-mannopyranoside
-
 Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.209 endoplasmic reticulum
-
 Candida albicans 5783
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.2.1.209 65000
-
 x * 65000, SDS-PAGE Candida albicans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.209 additional information Candida albicans enzyme is involved in the processing of N-linked mannans ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.209 Candida albicans Q8J0Q0 fragment; isoform Mns1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.209 4-methylumbelliferyl-alpha-D-mannopyranoside + H2O
-
 Candida albicans 4-methylumbelliferone + D-mannopyranose
-
 ?
3.2.1.209 Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-6)[Manalpha(1-2)Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + H2O
-
 Candida albicans Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)[Manalpha(1-2)Manalpha(1-6)[Manalpha(1-3)]Manalpha(1-6)]Manbeta(1-4)GlcNAcbeta(1-4)GlcNAc + D-mannose
-
 ?
3.2.1.209 additional information enzyme is involved in the processing of N-linked mannans Candida albicans ?
-
 ?
3.2.1.209 additional information no substrate: Man5glcNAc2-Asn Candida albicans ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.1.209 ? x * 65000, SDS-PAGE Candida albicans

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.209 37
-
-
 Candida albicans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.209 6
-
-
 Candida albicans

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.209 0.019
-
-
 Candida albicans 1-deoxymannojirimycin
3.2.1.209 0.62
-
-
 Candida albicans swainsonine