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Literature summary extracted from
- Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease? (2009), Med. Hypotheses, 72, 166-168.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.68 | additional information | in mice subjected to acute restraint stress, tPA activity is rapidly up-regulated in the amygdala | Mus musculus | |
| 3.4.21.68 | statins | can induce tPA and inhibits plasminogen activator inhibitor-1 | Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.68 | medicine | tPA-plasmin pathway dysfunction may play a role in the link between major depressive disorder and cardiovascular disease. Agents that modulate tPA-plasminogen activity may be potential drugs for the treatment of patients with both major depressive disorder and cardiovascular disease | Mus musculus |
| 3.4.21.68 | medicine | tPA-plasmin pathway dysfunction may play a role in the link between major depressive disorder and cardiovascular disease. Agents that modulate tPA-plasminogen activity may be potential drugs for the treatment of patients with both major depressive disorder and cardiovascular disease | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.21.68 | additional information | mice in which the tPA gene has been disrupted do not show anxiety after repeated stress | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.68 | plasminogen activator inhibitor-1 | is the major inhibitor of tPA-plasminogen signaling. Evidence for an association between plasminogen activator inhibitor-1 and cardiovascular disease pathogenesis | Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.68 | Homo sapiens | - |
- |
- |
| 3.4.21.68 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.68 | amygdala | - |
Mus musculus | - |
| 3.4.21.68 | blood | functions as a thrombolytic enzyme | Homo sapiens | - |
| 3.4.21.68 | brain | promotes events associated with synaptic plasticity and cell death, such as neurodegeneration and seizures | Homo sapiens | - |
| 3.4.21.68 | hippocampus | tPA-plasmin system is abundantly expressed | Homo sapiens | - |
| 3.4.21.68 | plasma | patients with depression show significantly lower plasma tPA concentrations than normal persons | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.68 | plasminogen + H2O | the tPA plasminogen proteolytic cascade is involved in the cleavage of probrain-derived neurotrophic factor to brain-derived neurotrophic factor, by which the direction of brain-derived neurotrophic factor action is controlled. Brain-derived neurotrophic factor is important for the pathogenesis of major depressive disorder | Homo sapiens | plasmin + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.68 | Tissue plasminogen activator | - |
Mus musculus |
| 3.4.21.68 | Tissue plasminogen activator | - |
Homo sapiens |
| 3.4.21.68 | tPA | - |
Mus musculus |
| 3.4.21.68 | tPA | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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