Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Krenn, B.M.; Gaudernak, E.; Holzer, B.; Lanke, K.; Van Kuppeveld, F.J.; Seipelt, J.
    Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections (2009), J. Virol., 83, 58-64.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.29 expressed in HeLa cells enterovirus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.29 hinokitiol the cleavage of the cellular eukaryotic translation initiation factor eIF4GI by 2A protease is abolished in the presence of hinokitiol, no significant amounts of eIF4GI cleavage products are found within 24 h of infection enterovirus
3.4.22.29 pyrithione the cleavage of the cellular eukaryotic translation initiation factor eIF4GI by 2A protease is abolished in the presence of pyrithione, no significant amounts of eIF4GI cleavage products are found within 24 h of infection enterovirus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.29 cellular eukaryotic translation initiation factor eIF4GI + H2O enterovirus
-
 peptides
-
 ?
3.4.22.29 cellular eukaryotic translation initiation factor eIF4GII + H2O enterovirus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.29 enterovirus
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.29 additional information
-
 around 50% cleavage of cellular eukaryotic translation initiation factor eIF4GI is obtained at 4 h postinfection enterovirus
3.4.22.29 additional information
-
 at 6 h and 8 h postinfection, cellular eukaryotic translation initiation factor eIF4GI is nearly completely processed into its typical cleavage products enterovirus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.29 cellular eukaryotic translation initiation factor eIF4GI + H2O
-
 enterovirus peptides
-
 ?
3.4.22.29 cellular eukaryotic translation initiation factor eIF4GII + H2O
-
 enterovirus peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.29 2A protease
-
 enterovirus