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Literature summary extracted from

  • Foley, J.H.; Nesheim, M.E.
    Soluble thrombomodulin partially corrects the premature lysis defect in FVIII-deficient plasma by stimulating the activation of thrombin activatable fibrinolysis inhibitor (2009), J. Thromb. Haemost., 7, 453-459.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.17.20 factor VIII TAFI activation increases in plasma as the concentration of factor VIII increases Homo sapiens

Application

EC Number Application Comment Organism
3.4.17.20 medicine the extent of TAFI activation over time in normal plasma and factor VIII deficient plasma (FVIII-DP) is analysed and it is determined whether soluble thrombomodulin can correct the lysis defect in factor VIII deficient plasma. TAFI activation increases as the concentration of factor VIII increases. Factor VIII at a level of 10% fully corrects the lysis defect in spite of the extent of TAFI activation being only one half that obtained with 100% factor VIII. In addition, thrombomodulin increases TAFI activation sufficiently to correct the premature lysis defect in factor VIII-deficient plasma Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.20 Homo sapiens
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.20 blood plasma
-
 Homo sapiens
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Synonyms

EC Number Synonyms Comment Organism
3.4.17.20 TAFI
-
 Homo sapiens
3.4.17.20 thrombin-activatable fibrinolysis inhibitor
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 Homo sapiens