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Literature summary extracted from
- The vitamin K cycle (2005), J. Thromb. Haemost., 3, 1873-1878.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 4.1.1.90 | medicine | warfarin therapy | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.90 | - |
Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.1.1.90 | L128R | warfarin resistent mutant | Homo sapiens |
| 4.1.1.90 | R58G | warfarin resistent mutant | Homo sapiens |
| 4.1.1.90 | V29L | warfarin resistent mutant | Homo sapiens |
| 4.1.1.90 | V45A | warfarin resistent mutant | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.90 | additional information | the carboxylase reaction is inhibited by sulfhydryl-specific reagents | Homo sapiens | |
| 4.1.1.90 | warfarin | - |
Homo sapiens |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.1.1.90 | endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.90 | additional information | Homo sapiens | vitamin K-dependent proteins require carboxylation for activity | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.90 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.90 | HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.90 | L-glutamate + CO2 + O2 + vitamin K hydroquinone | - |
Homo sapiens | gamma-carboxy-L-glutamate + vitamin K epoxide + H2O | - |
? | |
| 4.1.1.90 | additional information | vitamin K-dependent proteins require carboxylation for activity | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.90 | More | disulfide bond between cysteines 99 and 450, five transmembrane domains | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.90 | gamma glutamyl carboxylase | - |
Homo sapiens |
| 4.1.1.90 | GGCX | - |
Homo sapiens |
| 4.1.1.90 | glutamate carboxylase | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.90 | vitamin K | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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