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Literature summary extracted from

  • Chen, B.B.; Lin, H.; Hu, G.X.; Su, Y.; Zhou, H.Y.; Lian, Q.Q.; Cai, H.; Hardy, D.O.; Gu, D.Y.; Ge, R.S.
    The (+)- and (-)-gossypols potently inhibit human and rat 11beta-hydroxysteroid dehydrogenase type 2 (2009), J. Steroid Biochem. Mol. Biol., 113, 177-181.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 (+)-gossypol potent inhibitor of 11betaHSD2 Homo sapiens
1.1.1.B40 (+)-gossypol potent inhibitor of 11betaHSD2 Rattus norvegicus
1.1.1.B40 (+/-)-gossypol potent inhibitor of 11betaHSD2 Homo sapiens
1.1.1.B40 (+/-)-gossypol potent inhibitor of 11betaHSD2 Rattus norvegicus
1.1.1.B40 (-)-gossypol potent inhibitor of 11betaHSD2 Homo sapiens
1.1.1.B40 (-)-gossypol potent inhibitor of 11betaHSD2 Rattus norvegicus
1.1.1.B40 carbenoxolone
-
 Homo sapiens
1.1.1.B40 carbenoxolone
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 corticosterone + NAD+ Homo sapiens
-
 11-dehydrocorticosterone + NADH + H+
-
 ?
1.1.1.B40 corticosterone + NAD+ Rattus norvegicus
-
 11-dehydrocorticosterone + NADH + H+
-
 ?
1.1.1.146 corticosterone + NADP+ Homo sapiens
-
 11-dehydrocorticosterone + NADPH
-
 ?
1.1.1.146 corticosterone + NADP+ Rattus norvegicus
-
 11-dehydrocorticosterone + NADPH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Homo sapiens
-
-
-
1.1.1.B40 Rattus norvegicus
-
-
-
1.1.1.146 Homo sapiens
-
-
-
1.1.1.146 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 kidney
-
 Homo sapiens
-
1.1.1.B40 kidney
-
 Rattus norvegicus
-
1.1.1.146 Leydig cell
-
 Rattus norvegicus
-
1.1.1.146 liver
-
 Homo sapiens
-
1.1.1.146 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 corticosterone + NAD+
-
 Homo sapiens 11-dehydrocorticosterone + NADH + H+
-
 ?
1.1.1.B40 corticosterone + NAD+
-
 Rattus norvegicus 11-dehydrocorticosterone + NADH + H+
-
 ?
1.1.1.146 corticosterone + NADP+
-
 Homo sapiens 11-dehydrocorticosterone + NADPH
-
 ?
1.1.1.146 corticosterone + NADP+
-
 Rattus norvegicus 11-dehydrocorticosterone + NADPH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
 Rattus norvegicus
1.1.1.B40 11betaHSD2
-
 Homo sapiens
1.1.1.B40 11betaHSD2
-
 Rattus norvegicus
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Rattus norvegicus
1.1.1.146 11betaHSD1
-
 Homo sapiens
1.1.1.146 11betaHSD1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Homo sapiens
1.1.1.B40 NAD+
-
 Rattus norvegicus
1.1.1.146 NADP+
-
 Homo sapiens
1.1.1.146 NADP+
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.B40 0.00002
-
 pH and temperature not specified in the publication Homo sapiens carbenoxolone
1.1.1.B40 0.00005
-
 pH and temperature not specified in the publication Rattus norvegicus carbenoxolone
1.1.1.B40 0.00061
-
 pH and temperature not specified in the publication Rattus norvegicus (+)-gossypol
1.1.1.B40 0.00088
-
 pH and temperature not specified in the publication Rattus norvegicus (+/-)-gossypol
1.1.1.B40 0.00105
-
 pH and temperature not specified in the publication Homo sapiens (+)-gossypol
1.1.1.B40 0.00105
-
 pH and temperature not specified in the publication Homo sapiens (+/-)-gossypol
1.1.1.B40 0.00133
-
 pH and temperature not specified in the publication Rattus norvegicus (-)-gossypol
1.1.1.B40 0.0019
-
 pH and temperature not specified in the publication Homo sapiens (-)-gossypol