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Literature summary extracted from

  • Lota, R.K.; Olusanjo, M.S.; Dhanani, S.; Owen, C.P.; Ahmed, S.
    Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17beta-hydroxysteroid dehydrogenase (17beta-HSD3) (2008), J. Steroid Biochem. Mol. Biol., 111, 128-137.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.62 1-(4-hydroxy-phenyl)-butan-1-one weak inhibitor with 35.1% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-decan-1-one weak inhibitor with 28.2% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-dodecan-1-one weak inhibitor with 42.5% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-ethanone weak inhibitor with 20.8% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-heptan-1-one weak inhibitor with 47.6% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-hexan-1-one weak inhibitor with 45.7% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-octan-1-one weak inhibitor with 36.9% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-pentan-1-one weak inhibitor with 39.8% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-propan-1-one weak inhibitor with 17.5% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxy-phenyl)-undecan-1-one weak inhibitor with 30.6% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 1-(4-hydroxyphenyl)-nonan-1-one weak inhibitor with 36.3% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 2-phenylethyl (2E)-3-phenylprop-2-enoate
-
 Rattus norvegicus
1.1.1.62 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
-
 Rattus norvegicus
1.1.1.62 7-hydroxy-2-phenyl-4H-chromen-4-one
-
 Rattus norvegicus
1.1.1.62 7-hydroxyflavone weak inhibitor with 14.2% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 baicalein weak inhibitor with 7.2% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 cyclobutyl-(4-hydroxyphenyl)-methanone weak inhibitor with 43.9% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 cycloheptyl-(4-hydroxyphenyl)-methanone weak inhibitor with 47.2% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 cyclohexyl-(4-hydroxyphenyl)-methanone weak inhibitor with 47.2% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 cyclopentyl-(4-hydroxyphenyl)-methanone weak inhibitor with 49.5% inhibition at 0.1 mM Rattus norvegicus
1.1.1.62 N-benzyl-2-oxo-2H-chromene-3-carboxamide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.62 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 estradiol-17beta + NADP+
-
 Rattus norvegicus estrone + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.62 17beta-HSD1
-
 Rattus norvegicus
1.1.1.62 17beta-hydroxysteroid dehydrogenase type 1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.62 NADP+
-
 Rattus norvegicus