Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Abou El-Magd, R.; Park, H.; Kawazoe, T.; Iwana, S.; Ono, K.; Chung, S.; Miyano, M.; Yorita, K.; Sakai, T.; Fukui, K.
    The effect of risperidone on D-amino acid oxidase activity as a hypothesis for a novel mechanism of action in the treatment of schizophrenia (2009), J. Psychopharmacol. (Oxford), 2009, 1-13.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.4.3.3 drug development the enzyme is a target in schizophrenia treatment Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.3 recombinant expression in rat C6 cells Mus musculus
1.4.3.3 recombinant expression of the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.3 benzoate
-
 Homo sapiens
1.4.3.3 benzoate
-
 Mus musculus
1.4.3.3 benzoate
-
 Sus scrofa
1.4.3.3 risperidone
-
 Homo sapiens
1.4.3.3 risperidone
-
 Mus musculus
1.4.3.3 risperidone
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.3 peroxisome
-
 Mus musculus 5777
-
1.4.3.3 peroxisome
-
 Homo sapiens 5777
-
1.4.3.3 peroxisome
-
 Sus scrofa 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2 Mus musculus
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2 Homo sapiens
-
 pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2 Sus scrofa
-
 pyruvate + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.3 Homo sapiens
-
-
-
1.4.3.3 Mus musculus
-
-
-
1.4.3.3 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.4.3.3 flavoprotein
-
 Mus musculus
1.4.3.3 flavoprotein
-
 Homo sapiens
1.4.3.3 flavoprotein
-
 Sus scrofa

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.3 recombinant enzyme by ammonium sulfate fractionation, anion exchange chromatography, and dialysis Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.3 brain
-
 Mus musculus
-
1.4.3.3 brain
-
 Homo sapiens
-
1.4.3.3 brain
-
 Sus scrofa
-
1.4.3.3 epithelial cell
-
 Sus scrofa
-
1.4.3.3 kidney
-
 Mus musculus
-
1.4.3.3 kidney
-
 Homo sapiens
-
1.4.3.3 kidney
-
 Sus scrofa
-
1.4.3.3 liver
-
 Mus musculus
-
1.4.3.3 liver
-
 Homo sapiens
-
1.4.3.3 liver
-
 Sus scrofa
-
1.4.3.3 LLC-PK1 cell a renal epithelial cell line Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.3 D-alanine + H2O + O2
-
 Mus musculus pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Homo sapiens pyruvate + NH3 + H2O2
-
 ?
1.4.3.3 D-alanine + H2O + O2
-
 Sus scrofa pyruvate + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.3 DAO
-
 Mus musculus
1.4.3.3 DAO
-
 Homo sapiens
1.4.3.3 DAO
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.3 25
-
 assay at Mus musculus
1.4.3.3 25
-
 assay at Homo sapiens
1.4.3.3 25
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.3 8.3
-
 assay at Mus musculus
1.4.3.3 8.3
-
 assay at Homo sapiens
1.4.3.3 8.3
-
 assay at Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.3 FAD flavoenzyme Mus musculus
1.4.3.3 FAD flavoenzyme Homo sapiens
1.4.3.3 FAD flavoenzyme Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.3 additional information
-
 additional information inhibition kinetics with risperidone, in vivo inhibition of cellular DAO activity in LLC-PK1 cells and cytotoxicity, overview Homo sapiens
1.4.3.3 additional information
-
 additional information inhibition kinetics with risperidone, in vivo inhibition of cellular DAO activity in LLC-PK1 cells and cytotoxicity, overview Sus scrofa

General Information

EC Number General Information Comment Organism
1.4.3.3 physiological function the enzyme is involved in the development of schizophrenia, mechanism, overview Homo sapiens