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Literature summary extracted from

  • Matsumoto, K.; Shimizu, C.; Arao, T.; Andoh, M.; Katsumata, N.; Kohno, T.; Yonemori, K.; Koizumi, F.; Yokote, H.; Aogi, K.; Tamura, K.; Nishio, K.; Fujiwara, Y.
    Identification of predictive biomarkers for response to trastuzumab using plasma FUCA activity and N-glycan identified by MALDI-TOF-MS (2009), J. Proteome Res., 8, 457-462.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.2.1.51 medicine progression-free survival significantly longer in high FUCA activity group than in low FUCA activity group, not correlated to clinical response to trastuzumab but maybe useful as biomarker for predicting progression-free survival for trastuzumab treatment, serum FUCA activity correlates with early detection in hepatocellular carcinoma Homo sapiens
3.2.1.51 medicine may be useful as a biomarker for predicting the progression-free survival of for trastuzumab treatment Homo sapiens
3.2.1.127 medicine progression-free survival significantly longer in high FUCA activity group than in low FUCA activity group, not correlated to clinical response to trastuzumab but maybe useful as biomarker for predicting progression-free survival for trastuzumab treatment Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.2.1.127 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.51 4-nitrophenyl-alpha-L-fucopyranoside + H2O Homo sapiens
-
 4-nitrophenol + L-fucose
-
 ?
3.2.1.127 4-nitrophenyl-alpha-L-fucopyranoside + H2O Homo sapiens
-
 4-nitrophenol + L-fucose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.68 Homo sapiens Q9BYC5
-
-
3.2.1.51 Homo sapiens
-
-
-
3.2.1.127 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.68 blood plasma
-
 Homo sapiens
-
3.2.1.51 blood plasma
-
 Homo sapiens
-
3.2.1.51 blood serum
-
 Homo sapiens
-
3.2.1.51 breast cancer cell
-
 Homo sapiens
-
3.2.1.127 breast cancer cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.68 additional information
-
 average activity 2.0 U/l Homo sapiens
3.2.1.51 additional information
-
 5.5 micromol/min/l, progressive disease group Homo sapiens
3.2.1.51 additional information
-
 5.9 micromol/min/l, nonresponders to trastuzumab Homo sapiens
3.2.1.51 additional information
-
 6.1 micromol/min/l, spectrophotometer citrate buffer pH 4.5, 3 h incubation at 37°C, optical density at 405 nm, average over all patient Homo sapiens
3.2.1.51 additional information
-
 6.3 micromol/min/l, non-progressive disease group Homo sapiens
3.2.1.51 additional information
-
 7.2 micromol/min/l, responders to trastuzumab Homo sapiens
3.2.1.51 additional information
-
 average activity 6.1 U/l Homo sapiens
3.2.1.127 additional information
-
 5.5 micromol/min/l, progressive disease group Homo sapiens
3.2.1.127 additional information
-
 5.9 micromol/min/l, nonresponders to trastuzumab Homo sapiens
3.2.1.127 additional information
-
 6.1 micromol/min/l, spectrophotometer citrate buffer pH 4.5, 3 h incubation at 37 degree Celsius, optical density at 405 nm, average over all patient Homo sapiens
3.2.1.127 additional information
-
 6.3 micromol/min/l, non-progressive disease group Homo sapiens
3.2.1.127 additional information
-
 7.2 micromol/min/l, responders to trastuzumab Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine pH 7.0, 37°C, 6 h, reaction stopped by heating at 100°C for 1 min Homo sapiens GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine)
-
 ?
3.2.1.51 4-nitrophenyl-alpha-L-fucopyranoside assay at pH 4.5, 37°C for 3 h, reaction stopped by addition of borate buffer Homo sapiens ?
-
 ?
3.2.1.51 4-nitrophenyl-alpha-L-fucopyranoside + H2O
-
 Homo sapiens 4-nitrophenol + L-fucose
-
 ?
3.2.1.51 4-nitrophenyl-alpha-L-fucopyranoside + H2O substrate incubated with plasma sample of breast cancer patients treated with anti-cancer monoclonal antibody trastuzumbal Homo sapiens 4-nitrophenol + L-fucose
-
 ?
3.2.1.127 4-nitrophenyl-alpha-L-fucopyranoside + H2O
-
 Homo sapiens 4-nitrophenol + L-fucose
-
 ?
3.2.1.127 4-nitrophenyl-alpha-L-fucopyranoside + H2O substrate incubated with plasma sample of breast cancer patients treated with anti-cancer monoclonal antibody trastuzumbal Homo sapiens 4-nitrophenol + L-fucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.68 alpha1-6,fucosyltransferase
-
 Homo sapiens
2.4.1.68 FUT8
-
 Homo sapiens
3.2.1.51 alpha-L fucosidase
-
 Homo sapiens
3.2.1.51 alpha-L-fucosidase
-
 Homo sapiens
3.2.1.51 FucA
-
 Homo sapiens
3.2.1.127 alpha-L fucosidase
-
 Homo sapiens
3.2.1.127 FucA
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.68 37
-
 assay at Homo sapiens
3.2.1.51 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.68 7
-
 assay at Homo sapiens
3.2.1.51 4.5
-
 assay at Homo sapiens