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Literature summary extracted from

  • Warder, S.E.; Tucker, L.A.; McLoughlin, S.M.; Strelitzer, T.J.; Meuth, J.L.; Zhang, Q.; Sheppard, G.S.; Richardson, P.L.; Lesniewski, R.; Davidsen, S.K.; Bell, R.L.; Rogers, J.C.; Wang, J.
    Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition (2008), J. Proteome Res., 7, 4807-4820.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.18 A-357300 potent MetAP2 inhibitor Homo sapiens
3.4.11.18 A-357300 potent MetAP2 inhibitor Mus musculus
3.4.11.18 A-800141 potent MetAP2 inhibitor Homo sapiens
3.4.11.18 A-800141 potent MetAP2 inhibitor Mus musculus
3.4.11.18 fumagillin potent MetAP2 inhibitor Homo sapiens
3.4.11.18 fumagillin potent MetAP2 inhibitor Mus musculus
3.4.11.18 TNP-470 potent MetAP2 inhibitor Homo sapiens
3.4.11.18 TNP-470 potent MetAP2 inhibitor Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.18 Homo sapiens
-
-
-
3.4.11.18 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.11.18 Mono Q column chromatography and Q-Sepharose column chromatography Mus musculus
3.4.11.18 Mono Q column chromatography and Q-Sepharose column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.18 erythroleukemia cell
-
 Mus musculus
-
3.4.11.18 HT-1080 cell
-
 Homo sapiens
-
3.4.11.18 K-562 cell
-
 Homo sapiens
-
3.4.11.18 MEL cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.18 cyclophillin A + H2O MetAP2-specific substrate Mus musculus ?
-
 ?
3.4.11.18 cyclophillin A + H2O MetAP2-specific substrate Homo sapiens ?
-
 ?
3.4.11.18 eukaryotic elongation factor-2 + H2O MetAP2-specific substrate Mus musculus ?
-
 ?
3.4.11.18 eukaryotic elongation factor-2 + H2O MetAP2-specific substrate Homo sapiens ?
-
 ?
3.4.11.18 glyceraldehye 3-phosphate dehydrogenase + H2O MetAP2-specific substrate Mus musculus ?
-
 ?
3.4.11.18 glyceraldehye 3-phosphate dehydrogenase + H2O MetAP2-specific substrate Homo sapiens ?
-
 ?
3.4.11.18 L-Met-L-Pro-p-nitroanilide + H2O
-
 Mus musculus L-Met + L-Pro-p-nitroanilide
-
 ?
3.4.11.18 L-Met-L-Pro-p-nitroanilide + H2O
-
 Homo sapiens L-Met + L-Pro-p-nitroanilide
-
 ?
3.4.11.18 SH3 binding glutamic acid rich-like protein + H2O MetAP2-specific substrate Mus musculus ?
-
 ?
3.4.11.18 SH3 binding glutamic acid rich-like protein + H2O MetAP2-specific substrate Homo sapiens ?
-
 ?
3.4.11.18 thioredoxin-1 + H2O MetAP2-specific substrate Mus musculus ?
-
 ?
3.4.11.18 thioredoxin-1 + H2O MetAP2-specific substrate Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.18 MetAP2
-
 Mus musculus
3.4.11.18 MetAP2
-
 Homo sapiens
3.4.11.18 methionine aminopeptidase-2
-
 Mus musculus
3.4.11.18 methionine aminopeptidase-2
-
 Homo sapiens