Literature summary extracted from

Hwang, T.C.; Sheppard, D.N.
Gating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation (2009), J. Physiol., 587, 2151-2161.

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.6.1.6	Homo sapiens	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
5.6.1.6	phosphoprotein	phosphorylation of the unique regulatory domain by the cAMP-dependent protein kinase is a prerequisite for channel opening. CFTR phosphorylation by different kinases might 1. activate, e.g. cGMP-dependent protein kinase II, 2. inhibit, e.g.AMP-activated protein kinase, or 3. have dual effects on channel activity depending on the CFTR construct studied and the consensus phosphorylation site phosphorylated	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.6.1.6	ATP + H2O + closed Cl- channel	binding mode of ATP in the CFTR nucleotide-binding domain NBD1-NBD2 dimer, organisation of the ATP-binding sites in CFTR involving Walker A and B motifs, and the signature sequence LSGGQ, and conformational changes of the CFTR Cl- channel during channel gating, overview	Homo sapiens	ADP + phosphate + open Cl- channel	-	?
5.6.1.6	additional information	mechanism of action of small molecules that modulate CFTR channel gating	Homo sapiens	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
5.6.1.6	More	structure modelling, overview	Homo sapiens

Synonyms

EC Number	Synonyms	Comment	Organism
5.6.1.6	CFTR	-	Homo sapiens

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Release 2023.1 (January 2023)