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Literature summary extracted from

  • Zhang, Y.; Illarionov, B.; Bacher, A.; Fischer, M.; Georg, G.I.; Ye, Q.Z.; Vander Velde, D.; Fanwick, P.E.; Song, Y.; Cushman, M.
    A novel lumazine synthase inhibitor derived from oxidation of 1,3,6,8-tetrahydroxy-2,7-naphthyridine to a tetraazaperylenehexaone derivative (2007), J. Org. Chem., 72, 2769-2776.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.78 1,3,6,8-tetrahydroxynaphthyridine
-
 Schizosaccharomyces pombe
2.5.1.78 2,5,8,11-tetraaza-5,11-dihydro-4,10-dihydroxyperylene-1,3,6,7,9,12-hexaone
-
 Schizosaccharomyces pombe

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.78 Schizosaccharomyces pombe
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.78 0.266
-
-
 Schizosaccharomyces pombe

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.78 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + L-3,4-dihydroxybutan-2-one 4-phosphate
-
 Schizosaccharomyces pombe 6,7-dimethyl-8-(1-D-ribityl)lumazine + 2 H2O + phosphate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.5.1.78 0.022
-
 2,5,8,11-tetraaza-5,11-dihydro-4,10-dihydroxyperylene-1,3,6,7,9,12-hexaone pH 7.0, 37°C, phosphate buffer Schizosaccharomyces pombe
2.5.1.78 0.066
-
 2,5,8,11-tetraaza-5,11-dihydro-4,10-dihydroxyperylene-1,3,6,7,9,12-hexaone pH 7.0, 37°C, Tris buffer Schizosaccharomyces pombe
2.5.1.78 0.35
-
 1,3,6,8-tetrahydroxynaphthyridine pH 7.0, 37°C Schizosaccharomyces pombe