Literature summary extracted from

Yao, M.; Nguyen, T.V.; Rosario, E.R.; Ramsden, M.; Pike, C.J.
Androgens regulate neprilysin expression: role in reducing beta-amyloid levels (2008), J. Neurochem., 105, 2477-2488.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.24.11	androgen	androgens positively regulate neural expression of neprilysin in adult male rats	Rattus norvegicus
3.4.24.11	dihydrotestosterone	induces a time-dependent increase in neprilysin expression. Dihydrotestosterone also significantly decreases levels of amyloid beta in androgen receptor-expressing cells transfected with amyloid precursor protein, but does not affect levels of either full-length or non-amyloidogenic, soluble amyloid precursor protein. The dihydrotestosterone-induced decrease of amyloid beta is blocked by pharmacological inhibition of neprilysin. The dihydrotestosterone-mediated increase in neprilysin expression and decrease in amyloid beta levels are not observed in rat pheochromocytoma cell 12 lacking androgen receptor and blocked in androgen receptor-expressing cells by the antagonists, cyproterone acetate and flutamide	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.11	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.11	neuron	androgens positively regulate neural expression of neprilysin in adult male rats	Rattus norvegicus	-

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Release 2023.1 (January 2023)