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Literature summary extracted from

  • Murakami, M.; Ito, H.; Hagiwara, K.; Yoshida, K.; Sobue, S.; Ichihara, M.; Takagi, A.; Kojima, T.; Tanaka, K.; Tamiya-Koizumi, K.; Kyogashima, M.; Suzuki, M.; Banno, Y.; Nozawa, Y.; Murate, T.
    ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: The role of COUP-TFI (2010), J. Neurochem., 112, 511-520.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.138 all-trans retinoic acid inhibits ceramide kinase transkription in neuroblastoma cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ATP + ceramide Homo sapiens
-
 ADP + ceramide 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Homo sapiens Q8TCT0
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.138 brain
-
 Homo sapiens
-
2.7.1.138 SH-SY5Y cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.138 additional information
-
 enzyme activity is decreased during all-trans retinoic acid-induced neuronal differentiation of SH-SY5Y cells, all-trans retinoic acid reduces CERK protein and mRNA level in a time- and concentration-dependent manner, all-trans retinoic acid reduces cellular enzyme product ceramide 1-phosphate to 60% of control cells Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 ATP + ceramide
-
 Homo sapiens ADP + ceramide 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 ceramide kinase
-
 Homo sapiens
2.7.1.138 CERK
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.138 Homo sapiens all-trans retinoic acid inhibits ceramide kinase transkription during neuronal differentiation of a human neuroblastoma cell line SH-SY5Y, inhibition of the transcriptional activity of the 5'-promoter of ceramide kinase. Retinol does not reduce CERK protein and mRNA level down

General Information

EC Number General Information Comment Organism
2.7.1.138 physiological function enzyme plays an important role in cellular events such as cell growth and inflammation Homo sapiens