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Literature summary extracted from

  • Shi, Q.; Risa, O.; Sonnewald, U.; Gibson, G.E.
    Mild reduction in the activity of the alpha-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis (2009), J. Neurochem., 109 Suppl 1, 214-221.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.105 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.105 HEK-293 cell The HEK-293 subline E2k-67 shows about 30% reduced KGDHC activity; control line E2k-100 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Homo sapiens [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.105 alpha-ketoglutarate dehydrogenase complex
-
 Homo sapiens
1.2.1.105 E1k
-
 Homo sapiens
1.2.1.105 KGDHC
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.105 NAD+
-
 Homo sapiens