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Literature summary extracted from

  • de Mota, N.; Iturrioz, X.; Claperon, C.; Bodineau, L.; Fassot, C.; Roques, B.P.; Palkovits, M.; Llorens-Cortes, C.
    Human brain aminopeptidase A: biochemical properties and distribution in brain nuclei (2008), J. Neurochem., 106, 416-428.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.7
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.7 (S)-3-amino-4-mercapto-butylsulfonic acid specific and selective aminopeptidase A inhibitor Homo sapiens
3.4.11.7 (S)-3-amino-4-mercapto-butylsulfonic acid specific and selective APA inhibitor Mus musculus
3.4.11.7 2-amino-4-methylsulfonyl butane thiol weak inhibitor of aminopeptidase A Homo sapiens
3.4.11.7 2-amino-4-methylsulfonyl butane thiol weak inhibitor of APA Mus musculus
3.4.11.7 bestatin
-
 Homo sapiens
3.4.11.7 bestatin
-
 Mus musculus
3.4.11.7 captopril
-
 Homo sapiens
3.4.11.7 captopril
-
 Mus musculus
3.4.11.7 L-glutamate phosphinic acid
-
 Homo sapiens
3.4.11.7 L-glutamate phosphinic acid
-
 Mus musculus
3.4.11.7 methionine thiol
-
 Homo sapiens
3.4.11.7 methionine thiol
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.11.7 Ca2+ maximal activation at 4 mM Ca2+ Mus musculus
3.4.11.7 Ca2+ maximal activation at 4 mM Ca2+ Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.7 Homo sapiens
-
-
-
3.4.11.7 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.7 brain
-
 Mus musculus
-
3.4.11.7 brain
-
 Homo sapiens
-
3.4.11.7 choroid plexus
-
 Homo sapiens
-
3.4.11.7 hypothalamus highest activity Homo sapiens
-
3.4.11.7 medulla oblongata dorsomedial part, highest activity Homo sapiens
-
3.4.11.7 nucleus accumbens highest activity Homo sapiens
-
3.4.11.7 olfactory bulb highest activity Homo sapiens
-
3.4.11.7 paraventricular nucleus highest activity Homo sapiens
-
3.4.11.7 pineal gland
-
 Homo sapiens
-
3.4.11.7 prefrontal cortex highest activity Homo sapiens
-
3.4.11.7 spinal cord
-
 Homo sapiens
-
3.4.11.7 supraoptic nucleus highest activity Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.7 angiotensin II + H2O
-
 Mus musculus L-aspartic acid + angiotensin III
-
 ?
3.4.11.7 angiotensin II + H2O
-
 Homo sapiens L-aspartic acid + angiotensin III
-
 ?
3.4.11.7 L-Glu-2-naphthylamide + H2O
-
 Mus musculus L-Glu + 2-naphthylamine
-
 ?
3.4.11.7 L-Glu-2-naphthylamide + H2O
-
 Homo sapiens L-Glu + 2-naphthylamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.7 aminopeptidase A
-
 Mus musculus
3.4.11.7 aminopeptidase A
-
 Homo sapiens
3.4.11.7 APA
-
 Mus musculus
3.4.11.7 APA
-
 Homo sapiens