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Literature summary extracted from

  • Ha, D.T.; Ngoc, T.M.; Lee, I.; Lee, Y.M.; Kim, J.S.; Jung, H.; Lee, S.; Na, M.; Bae, K.
    Inhibitors of aldose reductase and formation of advanced glycation end-products in moutan cortex (Paeonia suffruticosa) (2009), J. Nat. Prod., 72, 1465-1470.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 3,3-Tetramethyleneglutaric acid
-
Rattus norvegicus
1.1.1.21 30-norhederagenin
-
Rattus norvegicus
1.1.1.21 4-O-butylpaeoniflorin
-
Rattus norvegicus
1.1.1.21 5-hydroxy-3S-hydroxymethyl-6-methyl-2,3-dihydrobenzofuran
-
Rattus norvegicus
1.1.1.21 6-methoxypaeoniflorigenone
-
Rattus norvegicus
1.1.1.21 8-O-benzoylpaeonidanin
-
Rattus norvegicus
1.1.1.21 alpha-benzoyloxypaeoniflorin
-
Rattus norvegicus
1.1.1.21 apiopaeonoside
-
Rattus norvegicus
1.1.1.21 benzoylpaeoniflorin
-
Rattus norvegicus
1.1.1.21 beta-benzoyloxypaeoniflorin
-
Rattus norvegicus
1.1.1.21 galloylpaeoniflorin
-
Rattus norvegicus
1.1.1.21 nudanpinoside H
-
Rattus norvegicus
1.1.1.21 oxypaeoniflorin
-
Rattus norvegicus
1.1.1.21 paeoniflorigenone
-
Rattus norvegicus
1.1.1.21 paeoniflorin
-
Rattus norvegicus
1.1.1.21 paeonol
-
Rattus norvegicus
1.1.1.21 paeonolide
-
Rattus norvegicus
1.1.1.21 paeonoside
-
Rattus norvegicus
1.1.1.21 palbinone
-
Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 DL-glyceraldehyde + NADPH + H+
-
Rattus norvegicus glycerol + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
Rattus norvegicus
1.1.1.21 RLAR
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.0114
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus palbinone
1.1.1.21 0.0288
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 30-norhederagenin
1.1.1.21 0.0318
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 3,3-Tetramethyleneglutaric acid
1.1.1.21 0.0362
-
in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 4-O-butylpaeoniflorin
1.1.1.21 0.0446
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus galloylpaeoniflorin
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeonol
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 8-O-benzoylpaeonidanin
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 5-hydroxy-3S-hydroxymethyl-6-methyl-2,3-dihydrobenzofuran
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeoniflorin
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus benzoylpaeoniflorin
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus oxypaeoniflorin
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus nudanpinoside H
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus alpha-benzoyloxypaeoniflorin
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus beta-benzoyloxypaeoniflorin
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeoniflorigenone
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus 6-methoxypaeoniflorigenone
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeonolide
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus paeonoside
1.1.1.21 0.05
-
IC50 above 0.05 mM, in 135 mM Na/K phosphate buffer (pH 7.0), 100 mM Li2SO4, at 37°C Rattus norvegicus apiopaeonoside