Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Graf, A.; Kabysheva, M.; Klimuk, E.; Trofimova, L.; Dunaeva, T.; ZĂ1/4ndorf, G.; Kahlert, S.; Reiser, G.; Storozhevykh, T.; Pinelis, V.; Sokolova, N.; Bunik, V.
    Role of 2-oxoglutarate dehydrogenase in brain pathologies involving glutamate neurotoxicity (2009), J. Mol. Catal. B, 61, 80-87.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.4.2 succinyl phosphonate OGDHC inhibitor competitive to 2-oxoglutarate, 0.005 mM succinyl phosphonate protects OGDHC from catalysis-induced inactivation Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.4.2 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.4.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.4.2 partial purification Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.4.2 brain cortex
-
 Rattus norvegicus
-
1.2.4.2 cerebellum
-
 Rattus norvegicus
-
1.2.4.2 hippocampus
-
 Rattus norvegicus
-
1.2.4.2 neuron hippocampal neuron Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.4.2 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
 Rattus norvegicus [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.4.2 2-oxoglutarate dehydrogenase complex
-
 Rattus norvegicus
1.2.4.2 OGDHC
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.4.2 NAD+
-
 Rattus norvegicus
1.2.4.2 thiamine diphosphate
-
 Rattus norvegicus