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Literature summary extracted from

  • Le, H.T.; Chaffotte, A.F.; Demey-Thomas, E.; Vinh, J.; Friguet, B.; Mary, J.
    Impact of hydrogen peroxide on the activity, structure, and conformational stability of the oxidized protein repair enzyme methionine sulfoxide reductase A (2009), J. Mol. Biol., 393, 58-66.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 expressed in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.4.11 H2O2 the enzyme is only inactivated by high doses of H2O2, when treated with 0.5 mM H2O2 MsrA loses 20% of its activity and this inhibition reaches approximately 40% with 1 mM H2O2, MsrA is not significantly inhibited by lower concentrations of H2O2 (0.050 and 0.1 mM) Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Rattus norvegicus Q923M1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 N-acetyl-L-methionine (S)-sulfoxide + thioredoxin
-
Rattus norvegicus N-acetyl-L-methionine + thioredoxin disulfide + H2O
-
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Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
Rattus norvegicus
1.8.4.11 MsrA
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
Rattus norvegicus