Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Grice, C.A.; Tays, K.L.; Savall, B.M.; Wei, J.; Butler, C.R.; Axe, F.U.; Bembenek, S.D.; Fourie, A.M.; Dunford, P.J.; Lundeen, K.; Coles, F.; Xue, X.; Riley, J.P.; Williams, K.N.; Karlsson, L.; Edwards, J.P.
    Identification of a potent, selective, and orally active leukotriene A4 hydrolase inhibitor with anti-inflammatory activity (2008), J. Med. Chem., 51, 4150-4169.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.3.2.6 expressed in Sf-9 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.6 (1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)methanol
-
 Homo sapiens
3.3.2.6 (1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)-carbamic acid tert-butyl ester
-
 Homo sapiens
3.3.2.6 (1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)-methanol
-
 Homo sapiens
3.3.2.6 1'-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl][1,4']bipiperidinyl-2-one
-
 Homo sapiens
3.3.2.6 1-(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)pyrrolidin-2-one
-
 Homo sapiens
3.3.2.6 1-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)pyrrolidin-2-one
-
 Homo sapiens
3.3.2.6 1-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]pyrrolidin-2-one
-
 Homo sapiens
3.3.2.6 1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]-4-phenylpiperidin-4-ol
-
 Homo sapiens
3.3.2.6 1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]piperidin-4-ol
-
 Homo sapiens
3.3.2.6 1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]-4-phenylpiperidin-4-ol
-
 Homo sapiens
3.3.2.6 1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-ol
-
 Homo sapiens
3.3.2.6 1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-ylamine
-
 Homo sapiens
3.3.2.6 1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidine-4-carboxylic acid amide
-
 Homo sapiens
3.3.2.6 1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-ol
-
 Homo sapiens
3.3.2.6 1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidine-4-carboxylic acid amide
-
 Homo sapiens
3.3.2.6 1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-ol
-
 Homo sapiens
3.3.2.6 1-[4-(benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid
-
 Homo sapiens
3.3.2.6 1-[4-(benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid amide
-
 Homo sapiens
3.3.2.6 2-(4-piperidin-1-ylmethylphenoxy)benzothiazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-azepan-1-ylethoxy)phenoxy]-1H-benzoimidazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-azepan-1-ylethoxy)phenoxy]benzooxazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-azepan-1-ylethoxy)phenoxy]benzothiazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-morpholin-4-ylethoxy)phenoxy]-1-(2-trimethylsilanylethoxymethyl)-1H-benzoimidazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-morpholin-4-ylethoxy)phenoxy]-1H-benzoimidazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-morpholin-4-ylethoxy)phenoxy]benzooxazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-morpholin-4-ylethoxy)phenoxy]benzothiazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-piperidin-1-ylethoxy)phenoxy]-1H-benzoimidazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-piperidin-1-ylethoxy)phenoxy]benzooxazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-piperidin-1-ylethoxy)phenoxy]benzothiazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-piperidin-1-ylethyl)phenoxy]benzothiazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]-1H-benzoimidazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]benzooxazole
-
 Homo sapiens
3.3.2.6 2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]benzothiazole
-
 Homo sapiens
3.3.2.6 3-(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)oxazolidin-2-one
-
 Homo sapiens
3.3.2.6 3-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)oxazolidin-2-one
-
 Homo sapiens
3.3.2.6 3-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]oxazolidin-2-one
-
 Homo sapiens
3.3.2.6 acetic acid (1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-ylcarbamoyl)methyl ester
-
 Homo sapiens
3.3.2.6 acetic acid [1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-ylcarbamoyl]methyl ester
-
 Homo sapiens
3.3.2.6 DG-051
-
 Homo sapiens
3.3.2.6 N-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)acetamide
-
 Homo sapiens
3.3.2.6 N-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]-2-hydroxyacetamide
-
 Homo sapiens
3.3.2.6 N-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]acetamide
-
 Homo sapiens
3.3.2.6 SC-57461A
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.6 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.3.2.6 Zn2+ contains zinc Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.6 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.3.2.6
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.6 leukotriene A4 + H2O
-
 Homo sapiens leukotriene B4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.6 leukotriene A4 hydrolase contains both hydrolase and aminopeptidase activity Homo sapiens
3.3.2.6 LTA4H
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.3.2.6 0.000004
-
-
 Homo sapiens 2-[4-(2-azepan-1-ylethoxy)phenoxy]benzooxazole
3.3.2.6 0.000006
-
-
 Homo sapiens 1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]-4-phenylpiperidin-4-ol
3.3.2.6 0.000007
-
-
 Homo sapiens 2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]benzooxazole
3.3.2.6 0.000008
-
-
 Homo sapiens 1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-ol
3.3.2.6 0.000008
-
-
 Homo sapiens N-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]-2-hydroxyacetamide
3.3.2.6 0.000009
-
-
 Homo sapiens 1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]piperidin-4-ol
3.3.2.6 0.00001
-
-
 Homo sapiens 3-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]oxazolidin-2-one
3.3.2.6 0.000011
-
-
 Homo sapiens 2-[4-(2-piperidin-1-ylethoxy)phenoxy]benzooxazole
3.3.2.6 0.000011
-
-
 Homo sapiens 3-(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)oxazolidin-2-one
3.3.2.6 0.000011
-
-
 Homo sapiens 1-[4-(benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid
3.3.2.6 0.000012
-
-
 Homo sapiens 1-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]pyrrolidin-2-one
3.3.2.6 0.000012
-
-
 Homo sapiens N-[1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-yl]acetamide
3.3.2.6 0.000013
-
-
 Homo sapiens (1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)-methanol
3.3.2.6 0.000013
-
-
 Homo sapiens 1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidine-4-carboxylic acid amide
3.3.2.6 0.000013
-
-
 Homo sapiens 1-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)pyrrolidin-2-one
3.3.2.6 0.000014
-
-
 Homo sapiens (1-[2-[4-(benzooxazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)methanol
3.3.2.6 0.000014
-
-
 Homo sapiens 2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]benzothiazole
3.3.2.6 0.000016
-
-
 Homo sapiens 1-(1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-yl)pyrrolidin-2-one
3.3.2.6 0.000017
-
-
 Homo sapiens 2-[4-(2-piperidin-1-ylethyl)phenoxy]benzothiazole
3.3.2.6 0.000017
-
-
 Homo sapiens 1-[4-(benzothiazol-2-yloxy)benzyl]piperidine-4-carboxylic acid amide
3.3.2.6 0.000021
-
-
 Homo sapiens acetic acid [1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-ylcarbamoyl]methyl ester
3.3.2.6 0.000028
-
-
 Homo sapiens 1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidine-4-carboxylic acid amide
3.3.2.6 0.000029
-
-
 Homo sapiens 3-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)oxazolidin-2-one
3.3.2.6 0.000031
-
-
 Homo sapiens 1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]piperidin-4-ol
3.3.2.6 0.000034
-
-
 Homo sapiens 1-[4-(benzothiazol-2-yloxy)benzyl]piperidin-4-ol
3.3.2.6 0.000035
-
-
 Homo sapiens N-(1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-yl)acetamide
3.3.2.6 0.00005
-
-
 Homo sapiens acetic acid (1-[2-[4-(benzothiazol-2-yloxy)phenyl]ethyl]piperidin-4-ylcarbamoyl)methyl ester
3.3.2.6 0.000054
-
-
 Homo sapiens 2-[4-(2-piperidin-1-ylethoxy)phenoxy]benzothiazole
3.3.2.6 0.000058
-
-
 Homo sapiens 2-[4-(2-morpholin-4-ylethoxy)phenoxy]benzooxazole
3.3.2.6 0.000059
-
-
 Homo sapiens 2-(4-piperidin-1-ylmethylphenoxy)benzothiazole
3.3.2.6 0.000066
-
-
 Homo sapiens 2-[4-(2-azepan-1-ylethoxy)phenoxy]benzothiazole
3.3.2.6 0.000066
-
-
 Homo sapiens 1-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl]-4-phenylpiperidin-4-ol
3.3.2.6 0.00007
-
-
 Homo sapiens 1'-[2-[4-(benzothiazol-2-yloxy)phenoxy]ethyl][1,4']bipiperidinyl-2-one
3.3.2.6 0.000084
-
-
 Homo sapiens 2-[4-(2-pyrrolidin-1-ylethoxy)phenoxy]-1H-benzoimidazole
3.3.2.6 0.00011
-
-
 Homo sapiens 2-[4-(2-piperidin-1-ylethoxy)phenoxy]-1H-benzoimidazole
3.3.2.6 0.00014
-
-
 Homo sapiens 2-[4-(2-azepan-1-ylethoxy)phenoxy]-1H-benzoimidazole
3.3.2.6 0.00035
-
-
 Homo sapiens 2-[4-(2-morpholin-4-ylethoxy)phenoxy]benzothiazole
3.3.2.6 0.003
-
-
 Homo sapiens 2-[4-(2-morpholin-4-ylethoxy)phenoxy]-1H-benzoimidazole