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Literature summary extracted from

  • Diczfalusy, U.; Olofsson, K.; Carlsson, A.; Gong, M.; Golenbock, D.; Rooyackers, O.; Fläring, U.; Björkbacka, H.
    Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide (2009), J. Lipid Res., 50, 2258-2264.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.99.38 lipopolysaccharide
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2 Mus musculus
-
 25-hydroxycholesterol + A + H2O
-
 ?
1.14.99.38 cholesterol + AH2 + O2 Homo sapiens
-
 25-hydroxycholesterol + A + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.29 Mus musculus
-
-
-
1.14.99.38 Homo sapiens
-
-
-
1.14.99.38 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.29 macrophage bone marrow-derived Mus musculus
-
1.14.99.38 macrophage
-
 Mus musculus
-
1.14.99.38 RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2
-
 Mus musculus 25-hydroxycholesterol + A + H2O
-
 ?
1.14.99.38 cholesterol + AH2 + O2
-
 Homo sapiens 25-hydroxycholesterol + A + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.29 cholesterol 25-hydroxylase
-
 Mus musculus
1.14.99.38 cholesterol 25-hydroxylase
-
 Mus musculus
1.14.99.38 cholesterol 25-hydroxylase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.14.29 Mus musculus lipopolysaccharide treatment does not increase the expression additional information