Literature summary extracted from

Ahmad, R.; Sylvester, J.; Ahmad, M.; Zafarullah, M.
Adaptor proteins and Ras synergistically regulate IL-1-induced ADAMTS-4 expression in human chondrocytes (2009), J. Immunol., 182, 5081-5087.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.24.82	IL-1beta	10 ng/ml, 20 min, upregulation of ADAMTS-4 only in presence of adaptor proteins MyD88, IRAK1 and TRAF6	Homo sapiens
3.4.24.82	TNF-alpha	10 ng/ml	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.24.82	additional information	down-regulation of IL-1beta-induced ADAMTS-4 activation by Ras knockdown or inhibition of reactive oxygen species by antioxidants along with ablation of MyD88, IRAK1, or TRAF6; inducing effect of IL-1beta partially blocked by knockdown of adaptor proteins MyD88, IRAK1 or TRAF6	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.B4	Homo sapiens	P45452	-	-
3.4.24.82	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.82	articular cartilage	-	Homo sapiens	-
3.4.24.82	chondrocyte	-	Homo sapiens	-
3.4.24.82	knee	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.B4	collagen type II + H2O	preferentially cleaves collagen type II	Homo sapiens	?	-	?
3.4.24.82	aggrecan + H2O	-	Homo sapiens	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.24.B4	collagenase-3	-	Homo sapiens
3.4.24.B4	matrix metalloproteinase-13	-	Homo sapiens
3.4.24.B4	MMP-13	-	Homo sapiens
3.4.24.82	ADAMTS-4	-	Homo sapiens
3.4.24.82	aggrecanase-1	-	Homo sapiens

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Release 2023.1 (January 2023)