EC Number | Application | Comment | Organism |
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3.4.24.83 | molecular biology | the effects of lethal toxin on the transcriptional regulation of the VCAM1 gene, which contains binding sites in its promoter region for NF-kappaB, IFN regulatory factor-1 (IRF-1), Sp1, GATA-2, and AP-1, in primary human endothelial cells is examined. Lethal toxin enhances cytokine-induced activation of NF-kappaB and IRF-1 which are key factors in the lethal toxin-mediated enhancement of TNF-induced VCAM-1 expression. Altering the activity of key transcription factors involved in host response to infection may be a critical mechanism by which lethal toxin contributes to anthrax pathogenesis | Bacillus anthracis |
EC Number | Organism | UniProt | Comment | Textmining |
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3.4.24.83 | Bacillus anthracis | - |
- |
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EC Number | Source Tissue | Comment | Organism | Textmining |
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EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.83 | anthrax lethal toxin | - |
Bacillus anthracis |