Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Revermann, M.; Barbosa-Sicard, E.; Dony, E.; Schermuly, R.T.; Morisseau, C.; Geisslinger, G.; Fleming, I.; Hammock, B.D.; Brandes, R.P.
    Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats (2009), J. Hypertens., 27, 322-331.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.10 12-(3-adamantan-1-yl-ureido)dodecanoic acid
-
 Rattus norvegicus
3.3.2.10 cis-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]benzoic acid
-
 Rattus norvegicus
3.3.2.10 additional information pulmonary sEH protein expression and activity are impaired in monocrotaline-treated rats Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.10 lung
-
 Rattus norvegicus
-
3.3.2.10 pulmonary artery smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.10 (5Z,11Z,14Z)-8,9-epoxyeicosa-5,11,14-trienoic acid + H2O i.e. 8,9-EET Rattus norvegicus (5Z,11Z,14Z)-8,9-dihydroxyeicosa-5,11,14-trienoic acid i.e. 8,9-DHET ?
3.3.2.10 (5Z,8Z,11Z)-14,15-epoxyeicosa-5,8,11-trienoic acid + H2O i.e. 14,15-EET Rattus norvegicus (5Z,8Z,11Z)-14,15-dihydroxyeicosa-5,8,11-trienoic acid i.e. 14,15-DHET ?
3.3.2.10 (5Z,8Z,14Z)-11,12-epoxyeicosa-5,8,14-trienoic acid + H2O i.e. 11,12-EET Rattus norvegicus (5Z,8Z,14Z)-11,12-dihydroxyeicosa-5,8,14-trienoic acid i.e. 11,12-DHET ?
3.3.2.10 (8Z,11Z,14Z)-5,6-epoxyeicosa-8,11,14-trienoic acid + H2O i.e. 5,6-EET Rattus norvegicus (8Z,11Z,14Z)-5,6-dihydroxyeicosa-8,11,14-trienoic acid i.e. 5,6-DHET ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.10 SEH
-
 Rattus norvegicus