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Literature summary extracted from

  • Tischler, J.L.; Abuaita, B.; Cuthpert, S.C.; Fage, C.; Murphy, K.; Saxe, A.; Furr, E.B.; Hedrick, J.; Meyers, J.; Snare, D.; Zand, A.R.
    Simple inhibitors of histone deacetylase activity that combine features of short-chain fatty acid and hydroxamic acid inhibitors (2008), J. Enzyme Inhib. Med. Chem., 23, 549-555.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.98 medicine application of HDAC inhibitors in cancer cell lines and mouse model systems leads to interruption of the cell cycle, differentiation and apoptosis, clinical studies have shown tumor repression and improvement of patient symptoms without significant side effects Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.98 3-benzoylbenzoic acid and hydroxamate analogs Rattus norvegicus
3.5.1.98 3-benzoylpropanoic acid and hydroxamate analogs Rattus norvegicus
3.5.1.98 4-benzoylbutyric acid and hydroxamate analogs Rattus norvegicus
3.5.1.98 4-benzoylbutyric hydroxamic acid
-
 Rattus norvegicus
3.5.1.98 4-phenylbutyric acid and hydroxamate analogs Rattus norvegicus
3.5.1.98 5-phenylvaleric acid and hydroxamate analogs Rattus norvegicus
3.5.1.98 5-phenylvaleric hydroxamic acid
-
 Rattus norvegicus
3.5.1.98 Butyric acid
-
 Rattus norvegicus
3.5.1.98 sodium butyrate
-
 Rattus norvegicus
3.5.1.98 suberoylanilide hydroxamic acid SAHA Rattus norvegicus
3.5.1.98 trichostatin A TSA Rattus norvegicus
3.5.1.98 Valproic acid
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.98 Zn2+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 AC-Arg-Gly-Lys(AC)-4-amino-7-methylcoumarin + H2O substrate activity assay Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC
-
 Rattus norvegicus
3.5.1.98 histone deacetylase
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.98 30
-
 activity assay Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.98 8.1
-
 activity assay Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.98 0.005
-
-
 Rattus norvegicus 5-phenylvaleric hydroxamic acid
3.5.1.98 0.133
-
-
 Rattus norvegicus 4-benzoylbutyric hydroxamic acid