EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.5.3.15 | Ca2+ | Ca2+ is not only the indispensable factor in the environment of deimination reaction, but is also considered as a major regulator of PAD genes at the transcriptional level | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.5.3.15 | Homo sapiens | Q6TGC4 | - |
- |
3.5.3.15 | Homo sapiens | Q9ULC6 | - |
- |
3.5.3.15 | Homo sapiens | Q9ULW8 | - |
- |
3.5.3.15 | Homo sapiens | Q9UM07 | - |
- |
3.5.3.15 | Homo sapiens | Q9Y2J8 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.5.3.15 | epidermis | isoform PAD2 is mainly detected in both the spinous and granular layers with a more intense staining of the latter | Homo sapiens | - |
3.5.3.15 | epidermis | isoform PAD3 expression is restricted to the granular layer and lower stratum corneum | Homo sapiens | - |
3.5.3.15 | epidermis | PAD1 is detected in the entire epidermis with an increasing intensity gradient from the basal to the granular layer | Homo sapiens | - |
3.5.3.15 | hair follicle | inner root sheath and cuticle of the hair follicles | Homo sapiens | - |
3.5.3.15 | keratinocyte | - |
Homo sapiens | - |
3.5.3.15 | medulla oblongata | - |
Homo sapiens | - |
3.5.3.15 | medulla oblongata | isoform PAD3 | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.5.3.15 | filaggrin L-Arg + H2O | - |
Homo sapiens | filaggrin citrulline + NH3 | - |
? | |
3.5.3.15 | S100A3-L-arginine + H2O | - |
Homo sapiens | S100A3-L-citrulline + NH3 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.5.3.15 | PAD1 | isoform | Homo sapiens |
3.5.3.15 | PAD2 | isoform | Homo sapiens |
3.5.3.15 | PAD3 | isoform | Homo sapiens |
3.5.3.15 | PAD4 | isoform | Homo sapiens |
3.5.3.15 | PAD6 | isoform | Homo sapiens |
3.5.3.15 | peptidylarginine deiminase | - |
Homo sapiens |