BRENDA - Enzyme Database

Invertebrate trypsins: a review

Muhlia-Almazan, A.; Sanchez-Paz, A.; Garcia-Carreno, F.L.; J. Comp. Physiol. B 178, 655-672 (2008)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.4.21.4
enteropeptidase
trypsinogen is activated through the cleavage of a peptide Val-Asp-Asp-Asp-Asp-Lys-Ile located on the N-terminus of the protein, the heptapetide is cleaved autocatalytically by its physiological activator, enteropeptidase
Bos taurus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.21.4
HgCl2
-
Sesamia nonagrioides
3.4.21.4
Lima bean trypsin inhibitor
-
Rhynchophorus ferrugineus
3.4.21.4
Lima bean trypsin inhibitor
-
Sesamia nonagrioides
3.4.21.4
phenylmethylsulfonyl fluoride
-
Astacus astacus
3.4.21.4
phenylmethylsulfonyl fluoride
-
Penaeus japonicus
3.4.21.4
phenylmethylsulfonyl fluoride
-
Penaeus paulensis
3.4.21.4
phenylmethylsulfonyl fluoride
-
Rhynchophorus ferrugineus
3.4.21.4
phenylmethylsulfonyl fluoride
-
Rhyzopertha dominica
3.4.21.4
phenylmethylsulfonyl fluoride
-
Triatoma infestans
3.4.21.4
Soybean trypsin inhibitor
-
Penaeus japonicus
3.4.21.4
Soybean trypsin inhibitor
-
Rhynchophorus ferrugineus
3.4.21.4
Soybean trypsin inhibitor
-
Rhyzopertha dominica
3.4.21.4
Soybean trypsin inhibitor
-
Sesamia nonagrioides
3.4.21.4
Soybean trypsin inhibitor
-
Triatoma infestans
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Astacus astacus
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Penaeus japonicus
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Penaeus paulensis
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Rhyzopertha dominica
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Triops sp.
3.4.21.4
trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane
-
Rhyzopertha dominica
3.4.21.4
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
Sesamia nonagrioides
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.4.21.4
additional information
not dependent on Ca2+ for activation or stability
Asterias amurensis
3.4.21.4
additional information
not dependent on Ca2+ for activation or stability
Musca domestica
3.4.21.4
additional information
not dependent on Ca2+ for activation or stability
Diatraea saccharalis
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.4.21.4
21700
-
-
Penaeus paulensis
3.4.21.4
24000
-
-
Rhyzopertha dominica
3.4.21.4
25000
-
-
Astacus astacus
3.4.21.4
25000
-
-
Penaeus japonicus
3.4.21.4
25000
-
-
Manduca sexta
3.4.21.4
26000
-
-
Cancer pagurus
3.4.21.4
26600
-
-
Musca domestica
3.4.21.4
28000
-
-
Asterias amurensis
3.4.21.4
28700
-
-
Diatraea saccharalis
3.4.21.4
31000
-
-
Sesamia nonagrioides
3.4.21.4
31000
-
-
Triops sp.
3.4.21.4
32000
-
-
Penaeus vannamei
3.4.21.4
40000
-
-
Triatoma infestans
Organism
EC Number
Organism
UniProt
Commentary
Textmining
3.4.21.4
Aedes aegypti
P29786
-
-
3.4.21.4
Astacus astacus
-
-
-
3.4.21.4
Asterias amurensis
-
-
-
3.4.21.4
Bos taurus
-
-
-
3.4.21.4
Cancer pagurus
-
-
-
3.4.21.4
Diaprepes abbreviatus
O76498
Sugarcane rootstalk borer weevil
-
3.4.21.4
Diatraea saccharalis
-
-
-
3.4.21.4
Lepeophtheirus salmonis
Q7YSS9
putative trypsin
-
3.4.21.4
Manduca sexta
P35045
tobacco hornworm moth
-
3.4.21.4
Musca domestica
-
-
-
3.4.21.4
Penaeus japonicus
-
-
-
3.4.21.4
Penaeus paulensis
-
-
-
3.4.21.4
Penaeus vannamei
Q9TY16
fragment; formerly Penaeus vannamei
-
3.4.21.4
Rhynchophorus ferrugineus
-
red palm weevil
-
3.4.21.4
Rhyzopertha dominica
-
-
-
3.4.21.4
Sesamia nonagrioides
-
-
-
3.4.21.4
Stomoxys calcitrans
O76519
-
-
3.4.21.4
Stomoxys calcitrans
O76520
-
-
3.4.21.4
Triatoma infestans
-
-
-
3.4.21.4
Triops sp.
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.21.4
animal
-
Musca domestica
-
3.4.21.4
gastric juice
-
Cancer pagurus
-
3.4.21.4
gut
-
Rhynchophorus ferrugineus
-
3.4.21.4
hepatopancreas
-
Astacus astacus
-
3.4.21.4
hepatopancreas
-
Sesamia nonagrioides
-
3.4.21.4
hepatopancreas
-
Rhyzopertha dominica
-
3.4.21.4
hepatopancreas
-
Penaeus japonicus
-
3.4.21.4
hepatopancreas
-
Penaeus paulensis
-
3.4.21.4
hepatopancreas
-
Manduca sexta
-
3.4.21.4
hepatopancreas
-
Penaeus vannamei
-
3.4.21.4
midgut
-
Diatraea saccharalis
-
3.4.21.4
midgut
-
Stomoxys calcitrans
-
3.4.21.4
pancreas
-
Bos taurus
-
3.4.21.4
pyloric cecum
-
Asterias amurensis
-
3.4.21.4
salivary gland
-
Triatoma infestans
-
3.4.21.4
whole body
-
Triops sp.
-
Synonyms
EC Number
Synonyms
Commentary
Organism
3.4.21.4
midgut-specific serine protease 1
-
Stomoxys calcitrans
3.4.21.4
midgut-specific serine protease 2
-
Stomoxys calcitrans
3.4.21.4
trypsin 3A1
-
Aedes aegypti
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.4.21.4
7
8
-
Astacus astacus
3.4.21.4
7
9.5
-
Rhyzopertha dominica
3.4.21.4
8
-
-
Asterias amurensis
3.4.21.4
8
-
-
Cancer pagurus
3.4.21.4
8
-
-
Triops sp.
3.4.21.4
8
8.3
-
Penaeus japonicus
3.4.21.4
8.5
-
-
Musca domestica
3.4.21.4
8.5
10.5
-
Sesamia nonagrioides
3.4.21.4
9
10
-
Rhynchophorus ferrugineus
3.4.21.4
10.5
-
-
Diatraea saccharalis
3.4.21.4
10.5
-
-
Manduca sexta
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.4.21.4
enteropeptidase
trypsinogen is activated through the cleavage of a peptide Val-Asp-Asp-Asp-Asp-Lys-Ile located on the N-terminus of the protein, the heptapetide is cleaved autocatalytically by its physiological activator, enteropeptidase
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.4.21.4
HgCl2
-
Sesamia nonagrioides
3.4.21.4
Lima bean trypsin inhibitor
-
Sesamia nonagrioides
3.4.21.4
Lima bean trypsin inhibitor
-
Rhynchophorus ferrugineus
3.4.21.4
phenylmethylsulfonyl fluoride
-
Astacus astacus
3.4.21.4
phenylmethylsulfonyl fluoride
-
Rhyzopertha dominica
3.4.21.4
phenylmethylsulfonyl fluoride
-
Penaeus japonicus
3.4.21.4
phenylmethylsulfonyl fluoride
-
Triatoma infestans
3.4.21.4
phenylmethylsulfonyl fluoride
-
Penaeus paulensis
3.4.21.4
phenylmethylsulfonyl fluoride
-
Rhynchophorus ferrugineus
3.4.21.4
Soybean trypsin inhibitor
-
Sesamia nonagrioides
3.4.21.4
Soybean trypsin inhibitor
-
Rhyzopertha dominica
3.4.21.4
Soybean trypsin inhibitor
-
Penaeus japonicus
3.4.21.4
Soybean trypsin inhibitor
-
Triatoma infestans
3.4.21.4
Soybean trypsin inhibitor
-
Rhynchophorus ferrugineus
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Astacus astacus
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Rhyzopertha dominica
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Penaeus japonicus
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Penaeus paulensis
3.4.21.4
tosyl-L-lysyl chloromethyl ketone
-
Triops sp.
3.4.21.4
trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane
-
Rhyzopertha dominica
3.4.21.4
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
Sesamia nonagrioides
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.4.21.4
additional information
not dependent on Ca2+ for activation or stability
Asterias amurensis
3.4.21.4
additional information
not dependent on Ca2+ for activation or stability
Musca domestica
3.4.21.4
additional information
not dependent on Ca2+ for activation or stability
Diatraea saccharalis
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.4.21.4
21700
-
-
Penaeus paulensis
3.4.21.4
24000
-
-
Rhyzopertha dominica
3.4.21.4
25000
-
-
Astacus astacus
3.4.21.4
25000
-
-
Penaeus japonicus
3.4.21.4
25000
-
-
Manduca sexta
3.4.21.4
26000
-
-
Cancer pagurus
3.4.21.4
26600
-
-
Musca domestica
3.4.21.4
28000
-
-
Asterias amurensis
3.4.21.4
28700
-
-
Diatraea saccharalis
3.4.21.4
31000
-
-
Sesamia nonagrioides
3.4.21.4
31000
-
-
Triops sp.
3.4.21.4
32000
-
-
Penaeus vannamei
3.4.21.4
40000
-
-
Triatoma infestans
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.4.21.4
animal
-
Musca domestica
-
3.4.21.4
gastric juice
-
Cancer pagurus
-
3.4.21.4
gut
-
Rhynchophorus ferrugineus
-
3.4.21.4
hepatopancreas
-
Astacus astacus
-
3.4.21.4
hepatopancreas
-
Sesamia nonagrioides
-
3.4.21.4
hepatopancreas
-
Rhyzopertha dominica
-
3.4.21.4
hepatopancreas
-
Penaeus japonicus
-
3.4.21.4
hepatopancreas
-
Penaeus paulensis
-
3.4.21.4
hepatopancreas
-
Manduca sexta
-
3.4.21.4
hepatopancreas
-
Penaeus vannamei
-
3.4.21.4
midgut
-
Diatraea saccharalis
-
3.4.21.4
midgut
-
Stomoxys calcitrans
-
3.4.21.4
pancreas
-
Bos taurus
-
3.4.21.4
pyloric cecum
-
Asterias amurensis
-
3.4.21.4
salivary gland
-
Triatoma infestans
-
3.4.21.4
whole body
-
Triops sp.
-
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
3.4.21.4
7
8
-
Astacus astacus
3.4.21.4
7
9.5
-
Rhyzopertha dominica
3.4.21.4
8
-
-
Asterias amurensis
3.4.21.4
8
-
-
Cancer pagurus
3.4.21.4
8
-
-
Triops sp.
3.4.21.4
8
8.3
-
Penaeus japonicus
3.4.21.4
8.5
-
-
Musca domestica
3.4.21.4
8.5
10.5
-
Sesamia nonagrioides
3.4.21.4
9
10
-
Rhynchophorus ferrugineus
3.4.21.4
10.5
-
-
Diatraea saccharalis
3.4.21.4
10.5
-
-
Manduca sexta