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Literature summary extracted from
- Role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila (2008), J. Comp. Physiol. B, 178, 27-32.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.22 | Juvenile hormone | - |
Drosophila virilis |  |
| 1.14.99.22 | L-dihydroxyphenylalanine | - |
Drosophila virilis | |
| 1.14.99.22 | octopamine | - |
Drosophila melanogaster | |
| 1.14.99.22 | octopamine | - |
Drosophila virilis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.22 | ecdysone + NADPH + O2 | Drosophila melanogaster | - |
20-hydroxyecdysone + NADP+ + H2O | - |
? | |
| 1.14.99.22 | ecdysone + NADPH + O2 | Drosophila virilis | - |
20-hydroxyecdysone + NADP+ + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.22 | Drosophila melanogaster | - |
wild-type strain Canton S, octopamineless strain Tbetah nM18 | - |
| 1.14.99.22 | Drosophila virilis | - |
wild-type strain 101 | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.22 | ecdysone + NADPH + O2 | - |
Drosophila melanogaster | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
| 1.14.99.22 | ecdysone + NADPH + O2 | - |
Drosophila virilis | 20-hydroxyecdysone + NADP+ + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.99.22 | E20MO | - |
Drosophila melanogaster |
| 1.14.99.22 | E20MO | - |
Drosophila virilis |
| 1.14.99.22 | ecdysone 20-monooxygenase | - |
Drosophila melanogaster |
| 1.14.99.22 | ecdysone 20-monooxygenase | - |
Drosophila virilis |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.22 | 35 | - |
activity assay | Drosophila melanogaster |
| 1.14.99.22 | 35 | - |
activity assay | Drosophila virilis |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.22 | 7.5 | - |
activity assay | Drosophila melanogaster |
| 1.14.99.22 | 7.5 | - |
activity assay | Drosophila virilis |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.22 | cytochrome P450 | - |
Drosophila melanogaster | |
| 1.14.99.22 | cytochrome P450 | - |
Drosophila virilis | |
| 1.14.99.22 | NADPH | - |
Drosophila melanogaster | |
| 1.14.99.22 | NADPH | - |
Drosophila virilis | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 1.14.99.22 | Drosophila virilis | L-dihydroxyphenylalanine and octopamine feeding increases ecdysone 20-monooxygenase activity by a factor of 1.6 and 1.7, respectively | up |
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