Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhou, L.; Yuan, J.; Yin, J.; Wang, E.
    Kinetic study of prolidase activity in erythrocytes against different substrates using capillary electrophoresis with electrochemiluminescence detection (2008), J. Chromatogr. A, 1200, 255-259.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.13.9 Colchicine colchicine enhances PLD activity for Gly-L-Pro and L-Leu-L-Pro, the highest enhancement of PLD on Gly-L-Pro is 141% at 0.01 mM Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.9 Colchicine colchicine has a slight inhibiting effect on prolidase activity for L-Val-L-Pro, the activity reaches its highest inhibition percentage of 59% at 2.0 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.13.9 0.243
-
L-Val-L-Pro in the presence of 0.1 mM colchicine, 1.0 mM Mn2+, in 30 mM phosphate buffer (pH 7.5) 5.0 mM Ru(bpy)32+, at 37°C Homo sapiens
3.4.13.9 0.269
-
L-Val-L-Pro in the absence of colchicine, 1.0 mM Mn2+, in 30 mM phosphate buffer (pH 7.5) 5.0 mM Ru(bpy)32+, at 37°C Homo sapiens
3.4.13.9 0.395
-
L-Leu-L-Pro in the presence of 0.1 mM colchicine, 1.0 mM Mn2+, in 30 mM phosphate buffer (pH 7.5) 5.0 mM Ru(bpy)32+, at 37°C Homo sapiens
3.4.13.9 0.628
-
L-Leu-L-Pro in the absence of colchicine, 1.0 mM Mn2+, in 30 mM phosphate buffer (pH 7.5) 5.0 mM Ru(bpy)32+, at 37°C Homo sapiens
3.4.13.9 2.13
-
Gly-L-Pro in the presence of 0.1 mM colchicine, 1.0 mM Mn2+, in 30 mM phosphate buffer (pH 7.5) 5.0 mM Ru(bpy)32+, at 37°C Homo sapiens
3.4.13.9 6.23
-
Gly-L-Pro in the absence of colchicine, 1.0 mM Mn2+, in 30 mM phosphate buffer (pH 7.5) 5.0 mM Ru(bpy)32+, at 37°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.13.9 Mn2+ required for activity Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.13.9 erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.9 Gly-L-Pro + H2O
-
Homo sapiens Gly + L-Pro
-
?
3.4.13.9 L-Leu-L-Pro + H2O
-
Homo sapiens L-Leu + L-Pro
-
?
3.4.13.9 L-Val-L-Pro + H2O
-
Homo sapiens L-Val + L-Pro
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.13.9 PLD
-
Homo sapiens
3.4.13.9 prolidase
-
Homo sapiens